Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

被引：11

作者：

Mischnik, Alexander ^{[1
,2
,11
]}

Baumert, Philipp ^{[1
,2
]}

Hamprecht, Axel ^{[1
,3
]}

Rohde, Anna ^{[1
,4
]}

Peter, Silke ^{[1
,5
]}

Feihl, Susanne ^{[1
,6
]}

Knobloch, Johannes ^{[1
,7
]}

Goelz, Hanna ^{[1
,8
]}

Kola, Axel ^{[1
,4
]}

Obermann, Birgit ^{[1
,9
]}

Querbach, Christiane ^{[1
,6
]}

Willmann, Matthias ^{[1
,5
]}

Gebhardt, Friedemann ^{[1
,6
]}

Tacconelli, Evelina ^{[1
,10
]}

Gastmeier, Petra ^{[1
]}

Seifert, Harald ^{[1
]}

Kern, Winfried V. ^{[1
,2
]}

机构：

[1] German Ctr Infect Res DZIF, Hannover, Germany

[2] Univ Freiburg, Univ Med Ctr Freiburg, Dept Med, Div Infect Dis, Freiburg, Germany

[3] Univ Hosp Cologne, Inst Med Microbiol Immunol & Hyg, Cologne, Germany

[4] Chari Univ Hosp Berlin, Natl Reference Ctr Surveillance Nosocomial Infect, Inst Hyg & Environm Med, Berlin, Germany

[5] Univ Tubingen, Inst Med Microbiol & Hygiene, Tubingen, Germany

[6] Tech Univ Munich, Inst Med Microbiol Immunol & Hygiene, Munich, Germany

[7] Univ Hamburg Eppendorf, Inst Med Mikrobiol Virol & Hygiene, Hamburg, Germany

[8] Univ Med Ctr Freiburg, Inst Med Microbiol & Hygiene, Freiburg, Germany

[9] Univ Hosp Schleswig Holstein, Inst Med Microbiol, Lubeck, Germany

[10] Univ Hosp Tubingen, Dept Internal Med 1, Div Infect Dis, Tubingen, Germany

[11] Univ Med Ctr Freiburg, Dept Med, Div Infect Dis, Hugstetter Str 55, D-79106 Freiburg, Germany

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2017年 / 49卷 / 02期

关键词：

Extended-spectrum beta-lactamase; ESBL; beta-Lactam; Avibactam; AmpC; IN-VITRO ACTIVITY; BETA-LACTAMASES; AVIBACTAM; COLONIZATION; CEFTAZIDIME; BACTEREMIA;

D O I：

10.1016/j.ijantimicag.2016.10.013

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

As part of the multicentre Antibiotic Therapy Optimisation Study (ATHOS), minimum inhibitory concentrations (MICs) were determined for cephalosporins alone and in combination with the beta-lactamase inhibitors tazobactam, clavulanic acid and avibactam against third-generation cephalosporin-resistant Escherichia coli, Klebsiella spp. and Enterobacter spp. isolates collected in German hospitals. MIC50/90 values were 0.254mg/L for cefepime/tazobactam, 0.25-2 mg/L for ceftazidime/avibactam, 0.125-0.5mg/L for ceftaroline/avibactam, 0.5-4 mg/L for cefpodoxime/clavulanic acid and 0.25-1 mg/L for aztreonam/avibactam, depending on the underlying resistance mechanism and organism. Based on in vitro testing, beta-lactam antibiotics play an important role in the treatment of infections due to beta-lactamase-producing organisms. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：239 / 242

页数：4

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