Factors Predicting Worse Outcomes in an Asian Cohort of Patients With Bronchiectasis

被引:2
作者
Kim, Kyu Yean [1 ]
Lee, Hwa Young [2 ]
Yeo, Chang Dong [1 ]
Lee, Eung Gu [1 ]
Kim, Seung Hoon [1 ]
Kim, Jin Woo [1 ,3 ]
机构
[1] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
[2] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Allergy, Seoul, South Korea
[3] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, 271, Seoul, Gyeonggi, South Korea
来源
IN VIVO | 2022年 / 36卷 / 06期
关键词
Bronchiectasis; Asian; bacterial colonization; CYSTIC FIBROSIS BRONCHIECTASIS; DISEASE SEVERITY; INDEX;
D O I
10.21873/invivo.13044
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background/Aim: Bronchiectasis has long been neglected, unlike chronic obstructive pulmonary disease (COPD) and asthma. Recent clinical trials have shown that long-term use of azithromycin or erythromycin reduce exacerbations of non-cystic fibrosis (non-CF) bronchiectasis. Because of this, we should actively try to treat patients susceptible to severe status. Patients and Methods: We enrolled patients who had been diagnosed with bronchiectasis at five branches of the Catholic Medical Center between January 2015 to December 2017. We retrospectively analyzed these patients for demographic characteristics such as sex, age, body mass index (BMI), history of smoking and tuberculosis, bacterial colonization, pulmonary function, hospitalizations, and other exacerbations. Results: Colonization was shown to have a statistically significant association with hospitalization. A three-year follow up period showed that the mean frequency of hospitalization in patients without colonization was 0.8 times, compared to 0.7 times and 1.9 times, respectively in patients with NTM colonization and with other bacterial colonization (p-value=0.03). Patients with a lower BMI also had an increased risk of hospitalization (p-value=0.024). Current smokers had increased risk of mortality as compared to those who had never smoked (HR=11.29, p-value 0.015). Patients with a high BMI also had low risk of mortality as compared to patients with a low BMI (HR=0.76, p-value 0.005). Conclusion: Patients with bronchiectasis having chronic colonization, low BMI, or who are current smokers tend to be at greater risk for severe illness. Therefore, physicians should actively treat these patients to prevent exacerbations and mortality.
引用
收藏
页码:2993 / 2998
页数:6
相关论文
共 50 条
[21]   Treatment adherence and health outcomes in patients with bronchiectasis [J].
Amanda R McCullough ;
Michael M Tunney ;
Alexandra L Quittner ;
J Stuart Elborn ;
Judy M Bradley ;
Carmel M Hughes .
BMC Pulmonary Medicine, 14
[22]   Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study [J].
Wang, Xuejie ;
Villa, Carmen ;
Dobarganes, Yadira ;
Olveira, Casilda ;
Giron, Rosa ;
Garcia-Clemente, Marta ;
Maiz, Luis ;
Sibila, Oriol ;
Golpe, Rafael ;
Menendez, Rosario ;
Rodriguez-Lopez, Juan ;
Prados, Concepcion ;
Angel Martinez-Garcia, Miguel ;
Luis Rodriguez, Juan ;
de la Rosa, David ;
Duran, Xavier ;
Barreiro, Esther .
BIOMEDICINES, 2021, 9 (08)
[23]   Comorbidities and mortality risk factors for patients with bronchiectasis [J].
Clofent, David ;
Alvarez, Antonio ;
Traversi, Letizia ;
Culebrasa, Mario ;
Loora, Karina ;
Polverinoar, Eva .
EXPERT REVIEW OF RESPIRATORY MEDICINE, 2021, 15 (05) :623-634
[24]   Risk factors for the development of bronchiectasis in patients with asthma [J].
Ma, Donghai ;
Cruz, Maria-Jesus ;
Ojanguren, Inigo ;
Romero-Mesones, Christian ;
Varona-Porres, Diego ;
Munoz, Xavier .
SCIENTIFIC REPORTS, 2021, 11 (01)
[25]   Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients [J].
Padilla-Galo, A. ;
Olveira, C. ;
Fernandez de Rota-Garcia, L. ;
Marco-Galve, I. ;
Plata, A. J. ;
Alvarez, A. ;
Rivas-Ruiz, F. ;
Carmona-Olveira, A. ;
Cebrian-Gallardo, J. J. ;
Martinez-Garcia, M. A. .
RESPIRATORY RESEARCH, 2018, 19
[26]   Analysis of the factors related to mortality in patients with bronchiectasis [J].
Pinar Onen, Zeynep ;
Eris Gulbay, Banu ;
Sen, Elif ;
Akkoca Yidiz, Oznur ;
Saryal, Sevgi ;
Acican, Turan ;
Karabiyikoglu, Guleren .
RESPIRATORY MEDICINE, 2007, 101 (07) :1390-1397
[27]   Socioeconomic features and predisposing factors in patients with bronchiectasis [J].
Ozdemir, Levent ;
Tabakoglu, Erhan ;
Hatipoglu, Osman Nuri ;
Altiay, Guendeniz ;
Ozlen, Burcu ;
Ciftci, Abdullah ;
Caglar, Tuncay .
TRAKYA UNIVERSITESI TIP FAKULTESI DERGISI, 2007, 24 (02) :98-100
[28]   Factors Affecting the Outcome of Bronchiectasis in Pediatric Patients [J].
Bilan, Nemat ;
Aghakhani, Mitra ;
Niafar, Farhad .
INTERNATIONAL JOURNAL OF PEDIATRICS-MASHHAD, 2014, 2 (04) :377-389
[29]   Microbiological factors of acute attack in patients with bronchiectasis [J].
Borekci, Sermin ;
Demir, Deniz ;
Zuhur, Cigdem ;
Musellim, Benan .
EUROPEAN RESPIRATORY JOURNAL, 2013, 42
[30]   Association between preserved ratio impaired spirometry and 1-year clinical outcomes in patients with bronchiectasis patients: A cohort study [J].
Gao, Fei ;
He, Siqi ;
Li, Jing ;
Wang, Xiaoyue ;
Chen, Xiaoting ;
Bu, Xiaoning .
RESPIRATORY INVESTIGATION, 2025, 63 (01) :163-169