A retrospective analysis of computed tomography findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation

被引：8

作者：

Ugai, Tomotaka ^{[1
]}

Hamamoto, Kohei ^{[2
]}

Kimura, Shun-ichi ^{[1
]}

Akahoshi, Yu ^{[1
]}

Nakano, Hirofumi ^{[1
]}

Harada, Naonori ^{[1
]}

Kameda, Kazuaki ^{[1
]}

Wada, Hidenori ^{[1
]}

Yamasaki, Ryoko ^{[1
]}

Ishihara, Yuko ^{[1
]}

Kawamura, Koji ^{[1
]}

Sakamoto, Kana ^{[1
]}

Ashizawa, Masahiro ^{[1
]}

Sato, Miki ^{[1
]}

Terasako-Saito, Kiriko ^{[1
]}

Nakasone, Hideki ^{[1
]}

Kikuchi, Misato ^{[1
]}

Yamazaki, Rie ^{[1
]}

Okochi, Tomohisa ^{[2
]}

Kanda, Junya ^{[1
]}

Kako, Shinichi ^{[1
]}

Tanaka, Osamu ^{[2
]}

Kanda, Yoshinobu ^{[1
]}

机构：

[1] Jichi Med Univ, Div Hematol, Saitama Med Ctr, Omiya Ku, Saitama, Saitama 3308503, Japan

[2] Jichi Med Univ, Dept Radiol, Saitama Med Ctr, Omiya Ku, Saitama, Saitama 3308503, Japan

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 2015年 / 84卷 / 12期

关键词：

CT findings; Pulmonary complication; Hematopoietic transplantation; BONE-MARROW-TRANSPLANTATION; PREEMPTIVE THERAPY; DISEASE; CT; INFECTIONS;

D O I：

10.1016/j.ejrad.2015.08.020

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objective: The purpose of this study was to review the high-resolution computed tomography (CT) findings in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation (HSCT), and to evaluate the relationship between CT findings and clinical outcomes. Patients and methods: We collected the clinical data in 96 consecutive patients who underwent CT scan for pulmonary complications after allogeneic HSCT and analyzed the relationships among these clinical characteristics, CT findings and clinical responses. Radiologists who were blinded to clinical information evaluated the CT findings. Results: In multivariate analyses, the presence of chronic graft-versus-host disease (GVHD) and nonsegmental multiple consolidations were significantly associated with a poor response to antimicrobial therapies, and the disease risk was significantly associated with a poor corticosteroid response. In addition, the existence of cavity formation and pleural effusion were significantly associated with a fatal prognosis. Twenty-five patients underwent bronchoscopic examination and 4 of them also underwent transbronchial lung biopsy (TBLB), but diagnostic information was not obtained in 15 patients. There was no significant association between specific CT findings and the diagnosis based on bronchoscopic examination. Conclusions: No specific CT finding was identified as a predictor for either an antimicrobial response or for a corticosteroid response in this study. The presence of cavity formation and pleural effusion may predict a poor prognosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：2663 / 2670

页数：8