Prognostic relevance of minimal residual disease in colorectal cancer

被引：31
作者：
Bork, Ulrich [1 ]
Gruetzmann, Robert [1 ]
Rahbari, Nuh N. [1 ]
Schoelch, Sebastian [1 ]
Distler, Marius [1 ]
Reissfelder, Christoph [1 ]
Koch, Moritz [1 ]
Weitz, Juergen [1 ]
机构：
[1] Tech Univ Dresden, Dept GI Thorac & Vasc Surg, Univ Hosp Dresden, D-01307 Dresden, Germany
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 30期
关键词：
Colorectal cancer; Circulating tumor cells; Disseminated tumor cells; Isolated tumor cells; Micrometastases; Occult disease; Minimal residual disease; CIRCULATING TUMOR-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; METASTATIC COLON-CANCER; PERIPHERAL-BLOOD; BREAST-CANCER; LYMPH-NODES; BONE-MARROW; MODEL; MICE; DISSEMINATION;
D O I：
10.3748/wjg.v20.i30.10296
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Presence of occult minimal residual disease in patients with colorectal cancer (CRC) has a strong prognostic impact on survival. Minimal residual disease plays a major role in disease relapse and formation of metastases in CRC. Analysis of circulating tumor cells (CTC) in the blood is increasingly used in clinical practice for disease monitoring of CRC patients. In this review article the role of CTC, disseminated tumor cells (DTC) in the bone marrow and micrometastases and isolated tumor cells (ITC) in the lymph nodes will be discussed, including literature published until September 2013. Occult disease is a strong prognostic marker for patient survival in CRC and defined by the presence of CTC in the blood, DTC in the bone marrow and/or micrometastases and ITC in the lymph nodes. Minimal residual disease could be used in the future to identify patient groups at risk, who might benefit from individualized treatment options. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
引用
收藏
页码：10296 / 10304
页数：9
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