The Cobalt-catalyzing Cross-Coupling Reaction of Alkyl Halides with Alkyl Grignard Reagents: A New Route to Constructing Quaternary Carbon Centers

被引：20

作者：

Iwasaki, Takanori ^{[1
]}

Takagawa, Hiroaki ^{[1
]}

Okamoto, Kanako ^{[1
]}

Singh, Surya Prakash ^{[2
]}

Kuniyasu, Hitoshi ^{[1
]}

Kambe, Nobuaki ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] CSIR Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500607, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 12期

关键词：

cobalt; cross-coupling; Grignard reagents; alkyl halides; quaternary carbon; 6-HALO-1-HEXENE DERIVATIVES; GROUP ISOMERIZATION; BOND FORMATION; NICKEL; SECONDARY; TOSYLATES; COMPLEXES; CATALYSTS; NI; PD;

D O I：

10.1055/s-0033-1341152

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cross-coupling of alkyl (pseudo)halides with alkyl Grignard reagents is catalyzed efficiently by a cobalt(II) chloride-lithium iodide-1,3-diene catalytic system, which provides a new synthetic tool for constructing sp(3) carbon chains. This system is particularly useful for creating quaternary carbon centers via the use of tertiary alkyl Grignard reagents. Various functional groups including esters, amides and carbamates are well tolerated.

引用

页码：1583 / 1592

页数：10

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