Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

被引：62
作者：
Halvaei, Iman [1 ]
Litzky, Julia [2 ]
Esfandiari, Navid [3 ]
机构：
[1] Tarbiat Modares Univ, Fac Med Sci, Dept Anat Sci, Tehran, Iran
[2] Dartmouth Hitchcock Med Ctr, Dept Pediat, Lebanon, NH 03766 USA
[3] Univ Vermont, Dept Obstet Gynecol & Reprod Sci, Med Ctr, Larner Coll Med, 111 Colchester Ave, Burlington, VT 05401 USA
来源：
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | 2020年 / 18卷 / 01期
关键词：
Male age; Aging; Pregnancy; Live birth; Sperm; IN-VITRO FERTILIZATION; LIVE-BIRTH-RATES; AUTISM SPECTRUM DISORDERS; ADVANCED PARENTAL AGE; SEMEN QUALITY; EMBRYO DEVELOPMENT; RISK-FACTORS; DNA-DAMAGE; LIFE-STYLE; PREGNANCY;
D O I：
10.1186/s12958-020-00668-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Many factors, including postponement of marriage, increased life expectancy, and improved success with assisted reproductive technologies have been contributing to increased paternal age in developed nations. This increased average paternal age has led to concerns about adverse effects of advanced paternal age on sperm quality, assisted reproductive outcomes, and the health of the offspring conceived by older fathers. This review discusses the association between advanced paternal age and sperm parameters, assisted reproduction success rates, and offspring health.
引用
收藏
页数：12
相关论文
共 129 条
[1]   Paternal age and outcome of intracytoplasmic sperm injection [J].
Aboulghar, Mohamed ;
Mansour, Ragaa ;
Al-Inany, Hesham ;
Abou-Setta, Ahmed M. ;
Aboulghar, Mona ;
Mourad, Latouna ;
Serour, Gamal .
REPRODUCTIVE BIOMEDICINE ONLINE, 2007, 14 (05) :588-592
[2]   Increasing Parental Age at Childbirth is Associated with Greater Insulin Sensitivity and More Favorable Metabolic Profile in Overweight Adult Male Offspring [J].
Albert, Benjamin B. ;
De Bock, Martin ;
Derraik, Jose G. B. ;
Brennan, Christine M. ;
Biggs, Janene B. ;
Hofman, Paul L. ;
Cutfield, Wayne S. .
AMERICAN JOURNAL OF HUMAN BIOLOGY, 2015, 27 (03) :380-386
[3]   The Effect of Paternal Age on Fetal Birth Outcomes [J].
Alio, Amina P. ;
Salihu, Hamisu M. ;
McIntosh, Cheri ;
August, Euna M. ;
Weldeselasse, Hanna ;
Sanchez, Emanny ;
Mbah, Alfred K. .
AMERICAN JOURNAL OF MENS HEALTH, 2012, 6 (05) :427-435
[4]   The role of antioxidants in sperm freezing: a review [J].
Amidi, Fardin ;
Pazhohan, Azar ;
Nashtaei, Maryam Shabani ;
Khodarahmian, Mahshad ;
Nekoonam, Saeid .
CELL AND TISSUE BANKING, 2016, 17 (04) :745-756
[5]   Is advanced paternal age a health risk for the offspring? [J].
Andersen, Anne-Marie Nybo ;
Urhoj, Stine Kjaer .
FERTILITY AND STERILITY, 2017, 107 (02) :312-318
[6]   Late paternity and stillbirth risk [J].
Astolfi, P ;
De Pasquale, A ;
Zonta, LA .
HUMAN REPRODUCTION, 2004, 19 (11) :2497-2501
[7]   Abnormal sperm concentration and motility as well as advanced paternal age compromise early embryonic development but not pregnancy outcomes: a retrospective study of 1266 ICSI cycles [J].
Bartolacci, Alessandro ;
Pagliardini, Luca ;
Makieva, Sofia ;
Salonia, Andrea ;
Papaleo, Enrico ;
Vigano, Paola .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2018, 35 (10) :1897-1903
[8]   Paternal age and assisted reproductive outcomes in ICSI donor oocytes: is there an effect of older fathers? [J].
Begueria, R. ;
Garcia, D. ;
Obradors, A. ;
Poisot, F. ;
Vassena, R. ;
Vernaeve, V. .
HUMAN REPRODUCTION, 2014, 29 (10) :2114-2122
[9]   Effect of maternal and paternal age on pregnancy and miscarriage rates after intrauterine insemination [J].
Belloc, Stephanie ;
Cohen-Bacrie, Paul ;
Benkhalifa, Moncef ;
Cohen-Bacrie, Martine ;
De Mouzon, Jacques ;
Hazout, Andre ;
Menezo, Yves .
REPRODUCTIVE BIOMEDICINE ONLINE, 2008, 17 (03) :392-397
[10]   How to overcome male infertility after 40: Influence of paternal age on fertility [J].
Belloc, Stephanie ;
Hazout, Andre ;
Zini, Armand ;
Merviel, Philippe ;
Cabry, Rosalie ;
Chahine, Hikmat ;
Copin, Henri ;
Benkhalifa, Moncef .
MATURITAS, 2014, 78 (01) :22-29
12345678910