Long telomere length predicts poor clinical outcome in esophageal cancer patients

被引:8
作者
Lv, Yanyan [1 ,2 ]
Zhang, Yong [3 ]
Li, Xinru [1 ]
Ren, Xiaojuan [1 ]
Wang, Meichen [1 ]
Tian, Sijia [1 ]
Hou, Peng [1 ,4 ]
Shi, Bingyin [1 ,4 ]
Yang, Qi [1 ,4 ]
机构
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian 710061, Peoples R China
[2] Xian 5 Hosp, Dept Rheumatol, Xian 710082, Peoples R China
[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Thorac Surg, Xian 710061, Peoples R China
[4] Xi An Jiao Tong Univ, Affiliated Hosp 1, Key Lab Tumor Precis Med Shaanxi Prov, Xian 710061, Peoples R China
基金
中国国家自然科学基金;
关键词
Esophageal cancer; Relative telomere length; Biomarker; Clinical outcome; REVERSE-TRANSCRIPTASE EXPRESSION; SQUAMOUS-CELL CARCINOMA; CHROMOSOMAL INSTABILITY; GASTRIC-CANCER; INCREASED RISK; LUNG-CANCER; LESIONS; CARCINOGENESIS; PROGRESSION; MECHANISMS;
D O I
10.1016/j.prp.2016.11.010
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Background: Abnormal telomere length is widely reported in various human cancers, and it is considered to be an important hallmark of cancer. However, there is remarkably little consensus on the value of telomere length in the prognostic evaluation of esophageal cancers. Here, we attempted to determine the association of variable telomere length with clinical outcome of esophageal cancer patients. Materials and methods: Using real-time quantitative PCR, we examined relative telomere lengths (RTL) in a cohort of esophageal cancer and normal esophageal tissues, and statistically investigated the association between RTL and clinical outcomes of esophageal cancer patients. Results: The majority of esophageal cancers in this study had longer RTLs as compared to adjacent non tumor tissues. Enhanced tumor RTL was associated with smoking habit, poor differentiation, advanced tumor stage, lymph node metastasis and cancer related death. In particular, a close relationship between longer RTL and poor survival was fully demonstrated by using cox regression and Kaplan-Maier survival curves. Conclusions: We found frequent telomere elongation in esophageal cancer tissues, and demonstrated longer RTL may be an independent poor prognostic factor for esophageal cancer patients. (C) 2016 Elsevier GmbH. All rights reserved.
引用
收藏
页码:113 / 118
页数:6
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