Synthesis and Vanilloid Receptor (TRPV1) Activity of the Enantiomers of α-Fluorinated Capsaicin

被引：26

作者：

Winkler, Margit ^{[1
,2
]}

Moraux, Thomas ^{[1
,2
]}

Khairy, Hesham A. ^{[3
]}

Scott, Roderick H. ^{[3
]}

Slawin, Alexandra M. Z. ^{[1
,2
]}

O'Hagan, David ^{[1
,2
]}

机构：

[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

[3] Univ Aberdeen, Inst Med Sci, Sch Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 05期

关键词：

capsaicin; fluorinated ligands; medicinal chemistry; organofluorine; stereoselective catalysis; C-F BOND; ANALGESIC AGENTS; AGONIST ACTIVITY; SENSORY NEURONS; ANALOGS; REGION; SENSITIVITY; CHEMISTRY; ALDEHYDES; AMIDES;

D O I：

10.1002/cbic.200800709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：823 / 828

页数：6

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