Role of IL-10 Deficiency in Pneumonia Induced by Corynebacterium kutscheri in Mice
被引:11
作者:
Jeong, Eui-Suk
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Konkuk Univ, Coll Vet Med, Seoul 143701, South Korea
Konkuk Univ, Coll Sci, Dept Biol Sci, Seoul 143701, South KoreaKonkuk Univ, Coll Vet Med, Seoul 143701, South Korea
Jeong, Eui-Suk
[1
,2
]
Won, Young-Suk
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Korea Res Inst Biosci & Biotechnol, Bioevaluat Ctr, Cheongwon 363883, Chungbuk, South KoreaKonkuk Univ, Coll Vet Med, Seoul 143701, South Korea
Won, Young-Suk
[3
]
Kim, Hyoung-Chin
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Korea Res Inst Biosci & Biotechnol, Bioevaluat Ctr, Cheongwon 363883, Chungbuk, South KoreaKonkuk Univ, Coll Vet Med, Seoul 143701, South Korea
Kim, Hyoung-Chin
[3
]
Cho, Myung-Hawn
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Konkuk Univ, Coll Sci, Dept Biol Sci, Seoul 143701, South KoreaKonkuk Univ, Coll Vet Med, Seoul 143701, South Korea
Cho, Myung-Hawn
[2
]
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Choi, Yang-Kyu
[1
]
机构:
[1] Konkuk Univ, Coll Vet Med, Seoul 143701, South Korea
[2] Konkuk Univ, Coll Sci, Dept Biol Sci, Seoul 143701, South Korea
[3] Korea Res Inst Biosci & Biotechnol, Bioevaluat Ctr, Cheongwon 363883, Chungbuk, South Korea
IL-10 is an important anti-inflammatory cytokine that can inhibit the production of many pro-inflammatory cytokines. Both human and animal studies have shown that pro-inflammatory cytokines play an important role in pneumonia and other inflammatory lung diseases. In the present study, IL-10 knockout (KO) and wild-type mice were infected with Corynebacterium kutscheri to determine whether the severity of pathogenesis and whether protective immunity could be altered in the absence of IL-10. The survival rate was significantly lower in IL-10 KO mice than wild-type mice. The number of neutrophils in bronchoalveolar lavage fluid and blood were found to be higher in IL-10 KO mice than wild-type mice. IL-10 KO mice showed greater neutrophil infiltration, excessive inflammation, and weight-loss compared with wild-type mice. Furthermore, upregulation of IFN-gamma in bronchoalveolar lavage fluid, and upregulation of MIP-1 alpha and IP-10 mRNA in the lungs of IL-10 KO mice compared with wild-type mice after C kutscheri infection were observed. These results suggest that IL-10 plays an important role in the anti-inflammatory properties against C kutscheri infection, and that lack of IL-10 leads to a more severe pulmonary inflammatory response. This increased susceptibility to C kutscheri pneumonia is at least in part caused by IL-10 deficiency and severe recruitment of neutrophils.
机构:
Vanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USAVanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USA
Du, CG
;
Sriram, S
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Vanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USAVanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USA
机构:
Vanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USAVanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USA
Du, CG
;
Sriram, S
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Vanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USAVanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USA