Hepcidin and its potential clinical utility

被引：14

作者：

Miseta, Attila ^{[1
]}

Nagy, Judit ^{[2
]}

Nagy, Tamas ^{[1
]}

Poor, Viktor Soma ^{[3
]}

Fekete, Zsuzsanna ^{[4
]}

Sipos, Katalin ^{[5
]}

机构：

[1] Univ Pecs, Fac Med Sci, Dept Lab Med, H-7624 Pecs, Hungary

[2] Univ Pecs, Fac Med Sci, Dept Anaesthesiol & Intens Care, H-7624 Pecs, Hungary

[3] Univ Pecs, Fac Med Sci, Dept Forens Med, H-7624 Pecs, Hungary

[4] Univ Pecs, Fac Med Sci, Dept Med Biol, H-7624 Pecs, Hungary

[5] Univ Pecs, Fac Med Sci, Dept Pharmaceut Biol, H-7624 Pecs, Hungary

来源：

CELL BIOLOGY INTERNATIONAL | 2015年 / 39卷 / 11期

关键词：

diagnostics; hepcidin; iron homeostasis; liver; prohepcidin; SYSTEMIC IRON HOMEOSTASIS; ANTIMICROBIAL PEPTIDE HEPCIDIN; REGULATORY HORMONE HEPCIDIN; CENTRAL-NERVOUS-SYSTEM; CHRONIC KIDNEY-DISEASE; PLASMA HEPCIDIN; SERUM HEPCIDIN; ANTIBACTERIAL ACTIVITY; HEREDITARY HEMOCHROMATOSIS; PROTEIN BIOGENESIS;

D O I：

10.1002/cbin.10505

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A number of pathophysiological conditions are related to iron metabolism disturbances. Some of them are well known, others are newly discovered or special. Hepcidin is a newly identified iron metabolism regulating hormone, which could be a promising biomarker for many disorders. In this review, we provide background information about mammalian iron metabolism, cellular iron trafficking, and the regulation of expression of hepcidin. Beside these molecular biological processes, we summarize the methods that have been used to determine blood and urine hepcidin levels and present those pathological conditions (cancer, inflammation, neurological disorders) when hepcidin measurement may have clinical relevance.

引用

页码：1191 / 1202

页数：12

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