Simple synthesis, self-assembly, and cytotoxicity of novel dimeric cholesterol derivatives

被引：10

作者：

Chou, Tzung-Han ^{[1
]}

Chen, Chien-Wen ^{[1
]}

Liang, Chia-Hua ^{[2
]}

Yeh, Li-Hsien ^{[1
]}

Qian, Shizhi ^{[3
]}

机构：

[1] Natl Yunlin Univ Sci & Technol, Dept Chem & Mat Engn, Yunlin 64002, Taiwan

[2] Chia Nan Univ Pharm & Sci, Dept Cosmet Sci, Tainan 717, Taiwan

[3] Old Dominion Univ, Inst Micro Nanotechnol, Norfolk, VA 23529 USA

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 116卷

关键词：

Dimeric cholesteryl derivatives; Self-assembly; Nano-structural aggregates; Cytotoxicity; HaCaT cells; AGGREGATED NANOPARTICLES; BILAYER-MEMBRANES; MODIFIED CHITOSAN; LIPID-MEMBRANE; DELIVERY; MONOLAYERS; VESICLES; GELATORS; POLYMER; DRUGS;

D O I：

10.1016/j.colsurfb.2013.12.044

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A simple and economic methodology to synthesize three types of novel dimeric cholesterol derivatives (DCDs) was developed. Results obtained from dynamic light scattering and transmission electron microscopy show that spherical and/or angular nano-structural aggregates of DCDs are formed by self-assembly in aqueous solution. The size and morphology of DCD dispersions depend on the spatial arrangement of the substituents and polarity of the head group in the DCD structures. The cytoxicity of DCD dispersions to human keratinocytes (HaCaT) and squamous cell carcinomas (SCC25) cells was also evaluated by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The present novel DCD dispersions were not toxic to HaCaT and SCC25 cells at appropriate tested concentrations. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.

引用

页码：153 / 159

页数：7

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