A New Furanocoumarin from the Roots of Angelica oncosepala

被引：1

作者：

Qing, Chen ^{[1
,2
]}

Zhou, Yi-Ping ^{[1
,2
]}

Zi, Rong ^{[3
]}

Zheng, Bin ^{[1
,2
]}

Luo, Ming ^{[1
,2
]}

Li, Xian ^{[1
,2
]}

机构：

[1] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China

[2] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China

[3] First Peoples Hosp Yunnan Prov, Dept Gynaecol, Kunming 650032, Yunnan, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Angelica oncosepala; furanocoumarin; oncosepalin B;

D O I：

10.1007/s10600-014-0924-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new furanocoumarin, 5-(2aEuro(3),3aEuro(3)-dihydroxy-3aEuro(3)-methylbutyloxy)-8-(2aEuro(3)aEuro(2)-hydroxy-3aEuro(3)aEuro(2)-methyl-3aEuro(3)aEuro(2)-butylenoxy)-psoralen, named oncosepalin B (1), was isolated from the roots of Angelica oncosepala. The structure of the new compound was identified on the basis of spectroscopic methods, especially extensive 1D and 2D NMR spectra analysis. Compound 1 showed weak inhibition of HL-60 human tumor cell line with an IC50 value of 17.05 mu M.

引用

页码：251 / 253

页数：3

共 4 条

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Zheng, Bin
Qing, Chen
Wang, Ji-Liang
Tang, Li-Ping
Li, Xian
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