Formation of new C-O and C-N bonds via base promoted Csp2-Csp3 bond cleavage of α-nitro ketone

被引：15

作者：

Sarma, Manas Jyoti ^{[1
]}

Borah, Arun Jyoti ^{[1
]}

Rajbongshi, Kamal Krishna ^{[1
]}

Phukan, Prodeep ^{[1
]}

机构：

[1] Gauhati Univ, Dept Chem, Gauhati 781014, Assam, India

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 50期

关键词：

C-C cleavage; alpha-Nitroketone; Bromamine-T; Esters; Amide; ACID METHYL-ESTER; ENANTIOSELECTIVE SYNTHESIS; METAL-FREE; ASYMMETRIC AMINOHYDROXYLATION; OXIDATIVE CLEAVAGE; MOLECULAR-OXYGEN; BROMAMINE-T; CARBON; ANTIBACTERIAL; ACTIVATION;

D O I：

10.1016/j.tetlet.2015.11.002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalyst free protocol has been developed for nucleophilic C-sp2 C-sp3 bond cleavage of alpha-nitroketone in the presence of potassium carbonate to create new C-O and C-N bonds. A series of different substituted alpha-nitroketones could be selectively cleaved and converted into corresponding esters and tosylamides in the presence of alcohols and bromamine-T, respectively. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：7008 / 7011

页数：4