-572 G/C single nucleotide polymorphism of interleukin-6 and sepsis predisposition in chronic renal disease

被引：11

作者：

Panayides, A. ^{[1
]}

Ioakeimidou, A. ^{[2
]}

Karamouzos, V. ^{[3
]}

Antonakos, N. ^{[4
]}

Koutelidakis, I. ^{[5
]}

Giannikopoulos, G. ^{[6
]}

Makaritsis, K. ^{[7
,8
]}

Voloudakis, N. ^{[5
]}

Toutouzas, K. ^{[9
]}

Rovina, N. ^{[10
,11
]}

Bristianou, M. ^{[12
]}

Damoraki, G. ^{[4
]}

Routsi, C. ^{[13
]}

Giamarellos-Bourboulis, E. J. ^{[4
,14
]}

机构：

[1] Nicosia Gen Hosp, Dept Nephrol, Nicosia, Cyprus

[2] Korinthos Gen Hosp, Intens Care Unit, Korinthos, Greece

[3] Rion Univ Hosp, Dept Internal Med, Patras, Greece

[4] Univ Athens, Sch Med, Dept Internal Med 4, GR-11527 Athens, Greece

[5] Aristotle Univ Thessaloniki, Dept Surg 2, GR-54006 Thessaloniki, Greece

[6] Chios Gen Hosp, Dept Internal Med, Chios, Greece

[7] Univ Thessaly, Sch Med, Dept Med, Larisa, Greece

[8] Univ Thessaly, Sch Med, Res Lab Internal Med, Larisa, Greece

[9] Univ Athens, Sch Med, Dept Propaedeut Surg 1, GR-11527 Athens, Greece

[10] Univ Athens, Sch Med, Dept Pulm Med 1, GR-11527 Athens, Greece

[11] Univ Athens, Sch Med, Intens Care Unit, GR-11527 Athens, Greece

[12] Lamia Gen Hosp, Dept Urol, Lamia, Greece

[13] Univ Athens, Sch Med, Dept Crit Care Med 1, GR-11527 Athens, Greece

[14] ATTIKON Univ Hosp, Dept Internal Med 4, Athens 12462, Greece

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2015年 / 34卷 / 12期

关键词：

C-REACTIVE PROTEIN; PROMOTER POLYMORPHISM; GENE POLYMORPHISMS; MORTALITY; ASSOCIATION; PROGRESSION; VARIANTS; SEVERITY; KIDNEY; RISK;

D O I：

10.1007/s10096-015-2500-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Single nucleotide polymorphisms (SNPs) of interleukin (IL)-6 are associated with the development of chronic renal disease (CRD). Their impact for sepsis in the field of CRD was investigated. One control cohort of 115 patients with CRD without infection and another case cohort of 198 patients with CRD and sepsis were enrolled. Genotyping at the -174 (rs1800795) and -572 positions of IL-6 (rs1800796) was done by restriction fragment length polymorphism. Circulating IL-6 was measured by an enzyme immunoassay. The GG genotype of rs1800796 was more frequent among cases (78.3 %) than controls (62.6 %). No difference in the genotype frequencies of rs1800795 between cases and controls were found. Odds ratio for sepsis was 2.07 (95%CI 1.24-3.44, p = 0.005) with the GG genotype of rs1800796, which was confirmed by logistic regression analysis taking into consideration the presence of chronic comorbidities. All-cause mortality until day 28 was similar between patients with the GG genotype and the GC/CC genotypes of rs1800796, but death caused from cardiovascular events not-related with infection was more frequent with the GG genotype (14.6 % vs 2.4 %, p = 0.031). Circulating IL-6 was greater among patients of the GC/CC genotypes of rs1800796 and multiple organ dysfunction (p = 0.013). The GG genotype of rs1800796 predisposes to sepsis in CRD and to 28-day mortality by sepsis-unrelated cardiovascular phenomena.

引用

页码：2439 / 2446

页数：8

共 25 条

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