Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome

被引：52

作者：

Allen, RP

Mignot, E

Ripley, B

Nishino, S

Earley, CJ

机构：

[1] Stanford Univ, Ctr Narcolepsy, Palo Alto, CA 94304 USA

[2] Stanford Univ, Sch Med, Dept Psychiat, Palo Alto, CA 94304 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21218 USA

来源：

NEUROLOGY | 2002年 / 59卷 / 04期

关键词：

D O I：

10.1212/WNL.59.4.639

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep disorder. Increases in CSF hypocretin-1 levels were most striking in patients with early-onset restless legs syndrome.

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页码：639 / 641

页数：3

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