RETRACTED: MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression (Retracted article. See April, 2017)

被引:55
作者
Long, Jianting [1 ]
Ou, Caiwen [2 ]
Xia, Haoming [3 ]
Zhu, Yifan [3 ]
Liu, Dayue [3 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Oncol, Guangzhou 510080, Guangdong, Peoples R China
[2] Southern Med Univ, Key Lab Construct & Detect Guangdong Prov, Guangzhou 510515, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Breast Dis Ctr, Dept Surg, Guangzhou 510080, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
miR-503; Breast cancer; CCND1; Cell proliferation; Cell cycle; TUMOR-SUPPRESSOR; COLORECTAL-CANCER; LUNG-CANCER; INVASION; ONCOGENE; TARGETS;
D O I
10.1007/s13277-015-3623-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer is one of the most common malignancies and a major cause of cancer-related mortality all over the world. A growing body of reports revealed that microRNAs play essential roles in the progression of cancers. Aberrant expression of miR-503 has been reported in several kinds of cancer. The aim of the current study was to elucidate the role of miR-503 in the pathogenesis of breast cancer. In the present study, our results suggested that miR-503 expression was markedly downregulated in breast cancer tissues and cells. Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G(0)/G(1) cell cycle arrest by targeting CCND1. Together, our findings provide new knowledge regarding the role of miR-503 in the progression of breast cancer and indicate the role of miR-503 as a tumor suppressor microRNA (miRNA) in breast cancer.
引用
收藏
页码:8697 / 8702
页数:6
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