RETRACTED: MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression (Retracted article. See April, 2017)

被引：55

作者：

Long, Jianting ^{[1
]}

Ou, Caiwen ^{[2
]}

Xia, Haoming ^{[3
]}

Zhu, Yifan ^{[3
]}

Liu, Dayue ^{[3
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Oncol, Guangzhou 510080, Guangdong, Peoples R China

[2] Southern Med Univ, Key Lab Construct & Detect Guangdong Prov, Guangzhou 510515, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Breast Dis Ctr, Dept Surg, Guangzhou 510080, Guangdong, Peoples R China

来源：

TUMOR BIOLOGY | 2015年 / 36卷 / 11期

基金：

中国国家自然科学基金;

关键词：

miR-503; Breast cancer; CCND1; Cell proliferation; Cell cycle; TUMOR-SUPPRESSOR; COLORECTAL-CANCER; LUNG-CANCER; INVASION; ONCOGENE; TARGETS;

D O I：

10.1007/s13277-015-3623-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is one of the most common malignancies and a major cause of cancer-related mortality all over the world. A growing body of reports revealed that microRNAs play essential roles in the progression of cancers. Aberrant expression of miR-503 has been reported in several kinds of cancer. The aim of the current study was to elucidate the role of miR-503 in the pathogenesis of breast cancer. In the present study, our results suggested that miR-503 expression was markedly downregulated in breast cancer tissues and cells. Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G(0)/G(1) cell cycle arrest by targeting CCND1. Together, our findings provide new knowledge regarding the role of miR-503 in the progression of breast cancer and indicate the role of miR-503 as a tumor suppressor microRNA (miRNA) in breast cancer.

引用

页码：8697 / 8702

页数：6

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