Cancer therapy using tumor-associated antigens to reduce side effects

被引：11

作者：

Siu, David ^{[1
]}

机构：

[1] Univ British Columbia, British Columbia Res Inst Childrens & Womens Hlth, Dept Obstet & Gynaecol, Vancouver, BC V5R 5K6, Canada

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2009年 / 9卷 / 03期

关键词：

Tumor-associated antigens; Monoclonal antibodies; Immune response; STEM-CELL ANTIGEN; HEPATOCYTE GROWTH-FACTOR; HYALURONAN-MEDIATED MOTILITY; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; C-MET; CARCINOEMBRYONIC ANTIGEN; ADHESION MOLECULE; RCAS1; EXPRESSION; PROGNOSTIC-SIGNIFICANCE;

D O I：

10.1007/s10238-009-0047-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tumor-associated antigens recently have become very popular in cancer therapy. They can be targeted to reduce side effects of traditional cancer therapy. In this review, ten promising tumor-associated antigens are being discussed in detail. The characteristics of each one are being reviewed in detail. Monoclonal antibodies attached to traditional anticancer agents can target a specific type of cancer cells thereby reducing the amount of traditional anticancer agents reaching normal tissues. This sort of cancer targeting can be a very attractive anticancer therapy because it substantially reduces the amount of side effects normally caused by traditional anticancer agents.

引用

页码：181 / 198

页数：18

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