Efficient chemoselective addition of Grignard reagents to carbonyl compounds in 2-methyltetrahydrofuran

被引：7

作者：

Zhong, Weihui ^{[1
]}

Wu, Yaotiao ^{[1
]}

Zhang, Xingxian ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Minist Educ, Key Lab Pharmaceut Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2009年 / 06期

基金：

中国国家自然科学基金;

关键词：

2-methyltetrahydrofuran; Grignard reactions; carbonyl compounds; alcohol synthesis; ALDEHYDES; ALCOHOLS; REARRANGEMENT; ALLYLATION; REDUCTION; COMPLEXES; MAGNESIUM; OXIDATION; SOLVENT; KETONES;

D O I：

10.3184/030823409X460939

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Compared with tetrahydrofuran (THF) as a solvent for the addition reactions between Grignard reagents and carbonyl compounds 2-methyltetrahydrofuran affords the corresponding adducts in higher yields with higher chemoselectivities. Moreover, 2-methyltetrahydrofuran can be readily recycled and reused, which lowers the cost of the process and makes the reaction greener.

引用

页码：370 / 373

页数：4

共 30 条

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