Synthesis and characterization of [(1R,2R)-trans-diaminocyclohexanelplatinum(II) coordinated to sulfur and selenium amino acids

被引：30

作者：

Rothenburger, Claudia

Galanski, Markus

Arion, Vladimir B.

Gorls, Helmar

Weigand, Wolfgang

Keppler, Bernhard K.

机构：

[1] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

[2] Univ Jena, Inst Anorgan & Analyt Chem, D-07743 Jena, Germany

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2006年 / 18期

关键词：

biomorganic chemistry; platinum; amino acids; sulfur; selenium;

D O I：

10.1002/ejic.200600453

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Dichloro[(1R,2R)-trans-diaminocyclohexane]platinum(II) was activated with Ag2CO3 and then treated with (S)-methionine, S-methyl-(S)-cysteine, (S)-selenomethionine and Se-methyl-seleno-(S)-cysteine. The N,S- and N,Se-chelated platinum(II) species were isolated as hexafluorophosphate salts and characterized by multinuclear NMR spectroscopy, ESI-MS, IR, elemental analyses and, in the case of the (S)-methionine and (S)-selenomethionine complexes, by X-ray crystallography. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006).

引用

页码：3746 / 3752

页数：7