Synthesis and characterization of [(1R,2R)-trans-diaminocyclohexanelplatinum(II) coordinated to sulfur and selenium amino acids

Dichloro[(1R,2R)-trans-diaminocyclohexane]platinum(II) was activated with Ag2CO3 and then treated with (S)-methionine, S-methyl-(S)-cysteine, (S)-selenomethionine and Se-methyl-seleno-(S)-cysteine. The N,S- and N,Se-chelated platinum(II) species were isolated as hexafluorophosphate salts and characterized by multinuclear NMR spectroscopy, ESI-MS, IR, elemental analyses and, in the case of the (S)-methionine and (S)-selenomethionine complexes, by X-ray crystallography. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006).