Synthesis and characterization of [(1R,2R)-trans-diaminocyclohexanelplatinum(II) coordinated to sulfur and selenium amino acids

被引：30
作者：
Rothenburger, Claudia
Galanski, Markus
Arion, Vladimir B.
Gorls, Helmar
Weigand, Wolfgang
Keppler, Bernhard K.
机构：
[1] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria
[2] Univ Jena, Inst Anorgan & Analyt Chem, D-07743 Jena, Germany
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2006年 / 18期
关键词：
biomorganic chemistry; platinum; amino acids; sulfur; selenium;
D O I：
10.1002/ejic.200600453
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Dichloro[(1R,2R)-trans-diaminocyclohexane]platinum(II) was activated with Ag2CO3 and then treated with (S)-methionine, S-methyl-(S)-cysteine, (S)-selenomethionine and Se-methyl-seleno-(S)-cysteine. The N,S- and N,Se-chelated platinum(II) species were isolated as hexafluorophosphate salts and characterized by multinuclear NMR spectroscopy, ESI-MS, IR, elemental analyses and, in the case of the (S)-methionine and (S)-selenomethionine complexes, by X-ray crystallography. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006).
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收藏
页码：3746 / 3752
页数：7
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