How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures

被引：141

作者：

Mullins, RD ^{[1
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Dept Cellular & Mol Pharmacol, San Francisco, CA 94129 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(99)00061-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In most cells, the structure of the actin cytoskeleton is regulated by Rho-family G proteins. Recent work has outlined a highly conserved signaling pathway from G protein activation to actin assembly. The key downstream components are WASP family proteins - adaptor molecules that bind multiple signaling and cytoskeletal proteins - and the Arp2/3 complex - a multi-functional protein complex that nucleates and crosslinks actin filaments.

引用

页码：91 / 96

页数：6

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