DNA replication with the mutagenic nucleotide dPTP; Effects of tautomerism on nucleotide incorporation

被引：0

作者：

Harris, VH ^{[1
]}

Smith, C ^{[1
]}

Cummins, J ^{[1
]}

Hamilton, A ^{[1
]}

Hornby, DP ^{[1
]}

Williams, DM ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Krebs Inst, Ctr Chem Biol, Sheffield S3 7HF, S Yorkshire, England

来源：

CHEMISTRY OF NUCLEIC ACID COMPONENTS | 2002年 / 5卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tautomeric constant of the nucleoside analogue P has been calculated and the kinetic parameters for the incorporation of dPTP by exo-Klenow have been determined. A strong correlation between the two suggests a role for the minor tautomeric forms of the bases in substitution mutagenesis during DNA replication.

引用

页码：215 / 220

页数：6

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