DNA replication with the mutagenic nucleotide dPTP; Effects of tautomerism on nucleotide incorporation

被引：0
|
作者：
Harris, VH [1 ]
Smith, C [1 ]
Cummins, J [1 ]
Hamilton, A [1 ]
Hornby, DP [1 ]
Williams, DM [1 ]
机构：
[1] Univ Sheffield, Dept Chem, Krebs Inst, Ctr Chem Biol, Sheffield S3 7HF, S Yorkshire, England
来源：
CHEMISTRY OF NUCLEIC ACID COMPONENTS | 2002年 / 5卷
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The tautomeric constant of the nucleoside analogue P has been calculated and the kinetic parameters for the incorporation of dPTP by exo-Klenow have been determined. A strong correlation between the two suggests a role for the minor tautomeric forms of the bases in substitution mutagenesis during DNA replication.
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页码：215 / 220
页数：6
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