Contrasting Effects of Intermittent and Continuous Hypoxia on Low O2 Evoked Catecholamine Secretion from Neonatal Rat Chromaffin Cells

被引：10

作者：

Souvannakitti, Dangjai ^{[1
]}

Kumar, Ganesh K. ^{[2
]}

Fox, Aaron ^{[4
]}

Prabhakar, Nanduri R. ^{[3
]}

机构：

[1] Univ Chicago, Dept Med, Ctr Syst Biol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Med, Ctr Syst Biol Oxygen Sensing, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Med, Ctr Syst Biol Sensing O2, Chicago, IL 60637 USA

[4] Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA

来源：

ARTERIAL CHEMORECEPTORS | 2009年 / 648卷

关键词：

Intermittent hypoxia; Chromaffin cells; Neonates; Recurrent apneas; CAROTID-BODY; RESPONSES; RELEASE;

D O I：

10.1007/978-90-481-2259-2_39

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In the present study we examined the effects of intermittent (IH) and sustained hypoxia (SH) on low PO2-evoked catecholamine (CA) secretion from neonatal rat chromaffin cells. Experiments were performed on chromaffin cells isolated from rat pups exposed to either IH (P0-P5; 15 s hypoxia-5 min normoxia;8 h/day) or SH (hypobaric hypoxia; 0.4ATM). CA secretion from chromaffin cells was monitored by amperometry. Control chromaffin cells, from P5 rat pups, exhibited robust CA secretion in response to acute hypoxia. IH facilitated whereas SH attenuated hypoxia-evoked CA secretion. IH increased the epinephrine and norepinephrine content of the adrenal medulla whereas SH had no effect. These results demonstrate that neonatal exposures IH and SH exert diametrically opposed effects on acute hypoxia-evoked CA secretion from chromaffin cells and CA contents.

引用

页码：345 / 349

页数：5

共 11 条

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