Epidermal nevus syndromes

被引:24
作者
Sugarman, JL
机构
[1] Univ Calif San Francisco, Dept Dermatol, Santa Rosa, CA 95404 USA
[2] Univ Calif San Francisco, Dept Community & Family Med, Santa Rosa, CA 95404 USA
关键词
D O I
10.1016/j.sder.2004.01.008
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The term "epidermal nevus syndrome" (ENS) has been used to describe the association of epidermal hamartomas and extra-cutaneous abnormalities. Epidermal nevi follow the lines of Blaschko. The majority of the extra-cutaneous manitestations involve the brain, eye, and skeletal systems. Several subsets with characteristic features have been delineated including the nevus sebaceous syndrome, Proteus syndrome, CHILD syndrome, Becker nevus syndrome, nevus comedonicus syndrome, and phakomatosis pigmentokeratotica. Epidermal nevi have been associated with benign and malignant neoplasms. Advances in molecular biology have revealed that the manifestations of ENS are due to genomic mosaicism. It is likely that the varied clinical manifestations of ENS are due in great part to the functional effects of specific genetic defects. Optimal management of the patient with ENS involves an interdisciplinary approach. Amelioration of the cutaneous features of ENS has been difficult but there have been advances, especially in the use of lasers. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:145 / 157
页数:13
相关论文
共 90 条
[1]   POROKERATOTIC ECCRINE OSTIAL AND DERMAL DUCT NEVUS [J].
ABELL, E ;
READ, SI .
BRITISH JOURNAL OF DERMATOLOGY, 1980, 103 (04) :435-441
[2]   BIRTHMARKS WITH SERIOUS MEDICAL SIGNIFICANCE - NEVOCELLULAR-NEVI, SEBACEOUS-NEVI, AND MULTIPLE CAFE-AU-LAIT SPOTS [J].
ALPER, J ;
HOLMES, LB ;
MIHM, MC .
JOURNAL OF PEDIATRICS, 1979, 95 (05) :696-700
[3]   INFLAMMATORY LINEAR VERRUCOSE EPIDERMAL NEVUS [J].
ALTMAN, J ;
MEHREGAN, AH .
ARCHIVES OF DERMATOLOGY, 1971, 104 (04) :385-&
[4]   VITAMIN-D-RESISTANT RICKETS ASSOCIATED WITH EPIDERMAL NEVUS SYNDROME - DEMONSTRATION OF A PHOSPHATURIC SUBSTANCE IN DERMAL LESIONS [J].
ASCHINBERG, LC ;
SOLOMON, LM ;
ZEIS, PM ;
JUSTICE, P ;
ROSENTHAL, IM .
JOURNAL OF PEDIATRICS, 1977, 91 (01) :56-60
[5]   NEVOID PSORIASIS [J].
ATHERTON, DJ ;
KAHANA, M ;
RUSSELLJONES, R .
BRITISH JOURNAL OF DERMATOLOGY, 1989, 120 (06) :837-841
[6]   NEUROLOGIC COMPLICATIONS OF THE EPIDERMAL NEVUS SYNDROME [J].
BAKER, RS ;
ROSS, PA ;
BAUMANN, RJ .
ARCHIVES OF NEUROLOGY, 1987, 44 (02) :227-232
[7]   SHAVE EXCISION AND PHENOL PEELING OF GENERALIZED VERRUCOUS EPIDERMAL NEVUS [J].
BAZEX, J ;
ELSAYED, F ;
SANS, B ;
BELHAOUARI, L ;
LARREGUE, M ;
MARCHAC, D .
DERMATOLOGIC SURGERY, 1995, 21 (08) :719-722
[8]  
Biesecker LG, 1999, AM J MED GENET, V84, P389, DOI 10.1002/(SICI)1096-8628(19990611)84:5<389::AID-AJMG1>3.0.CO
[9]  
2-O
[10]   CO2 laser treatment of epidermal nevi:: Long-term success [J].
Boyce, S ;
Alster, TS .
DERMATOLOGIC SURGERY, 2002, 28 (07) :611-614