Degradation of Human α- and β-Defensins by Culture Supernatants of Porphyromonas gingivalis Strain 381

被引：53
作者：
Carlisle, M. D. [2 ]
Srikantha, R. N. [1 ]
Brogden, K. A. [1 ,2 ]
机构：
[1] Univ Iowa, Coll Dent, Dows Inst Dent Res, Iowa City, IA 52242 USA
[2] Univ Iowa, Coll Dent, Dept Periodont, Iowa City, IA 52242 USA
来源：
JOURNAL OF INNATE IMMUNITY | 2009年 / 1卷 / 02期
关键词：
Defensins; Porphyromonas gingivalis; Proteases; Gingipains; ANTIMICROBIAL PEPTIDES; PERIODONTAL-DISEASE; HUMAN BETA-DEFENSIN-2; SUBGINGIVAL PLAQUE; VIRULENCE FACTORS; INNATE IMMUNITY; PROTEINASES; GINGIPAINS; BACTERIA; EXPRESSION;
D O I：
10.1159/000181015
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins and some antimicrobial peptides. In this study, we show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 min. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions. Copyright (C) 2008 S. Karger AG, Basel
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页码：118 / 122
页数：5
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