Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size

被引：24

作者：

Ellipilli, Satheesh ^{[1
]}

Murthy, Raghavendra Vasudeva ^{[1
]}

Ganesh, Krishna N. ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Chem Biol Unit, Pune 411008, Maharashtra, India

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 03期

关键词：

ANTISENSE OLIGONUCLEOTIDES; RNA INTERFERENCE; DELIVERY; BINDING; GENE; THERAPEUTICS; INHIBITION; TELOMERASE; ANALOGS; DNA/RNA;

D O I：

10.1039/c5cc05342k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Perfluoro undecanoyl chain conjugated peptide nucleic acids (PNAs) show 2.5 to 3 fold higher cellular uptake efficiency in NIH 3T3 and HeLa cells compared to simple undecanoyl PNAs. Fluorination of PNAs leads to the formation of lower size (similar to 100-250 nm) nanoparticles compared to larger size (similar to 500 nm) nanoparticles from non-fluorinated PNAs, thereby improving the efficiency of cell penetration.

引用

页码：521 / 524

页数：4

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