Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi

被引：11

作者：

Alves de Paula e Silva, Ana Carolina ^{[1
]}

Costa-Orlandi, Caroline Barcelos ^{[1
]}

Gullo, Fernanda Patricia ^{[1
]}

Sangalli-Leite, Fernanda ^{[1
]}

de Oliveira, Haroldo Cesar ^{[1
]}

da Silva, Julhiany de Fatima ^{[1
]}

Scorzoni, Liliana ^{[1
]}

Pitangui, Nayla de Souza ^{[1
]}

Rossi, Suelen Andrea ^{[1
]}

Benaducci, Tatiane ^{[1
]}

Wolf, Vanessa Goncalves ^{[1
]}

Regasini, Luis Octavio ^{[2
]}

Petronio, Maicon Segalla ^{[2
]}

Siqueira Silva, Dulce Helena ^{[2
]}

Bolzani, Vanderlan S. ^{[2
]}

Fusco-Almeida, Ana Marisa ^{[1
]}

Soares Mendes-Giannini, Maria Jose ^{[1
]}

机构：

[1] Univ Estadual Paulista Julio Mesquita Filho UNESP, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14800901 Araraquara, SP, Brazil

[2] Univ Estadual Paulista Julio Mesquita Filho UNESP, Inst Quim, Dept Quim Organ, BR-14800060 Araraquara, SP, Brazil

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2014年 / 2014卷

基金：

巴西圣保罗研究基金会;

关键词：

GALLIC ACID; INVASIVE MYCOSES; AMPHOTERICIN-B; ALKYL-ESTERS; IN-VITRO; AGENTS; DERIVATIVES; RESISTANCE; ASSAY;

D O I：

10.1155/2014/506273

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14) compound contributed to increase the antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, according to standardized microdilution method described by Clinical Laboratory Standard Institute (CLSI) documents. Moreover this compound has a particularly good selectivity index value, which makes it an excellent candidate for broad-spectrum antifungal prototype and encourages the continuation of subsequent studies for the discovery of its mechanism of action.

引用

页数：8

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