Metastatic Spine Disease: Should Patients With Short Life Expectancy Be Denied Surgical Care? An International Retrospective Cohort Study

被引:60
作者
Dea, Nicolas [1 ]
Versteeg, Anne L. [2 ]
Sahgal, Arjun [3 ]
Verlaan, Jorrit-Jan [2 ]
Charest-Morin, Raphaele [1 ]
Rhines, Laurence D. [4 ]
Sciubba, Daniel M. [5 ]
Schuster, James M. [6 ]
Weber, Michael H. [7 ]
Lazary, Aron [8 ]
Fehlings, Michael G. [9 ]
Clarke, Michelle J. [10 ]
Arnold, Paul M. [11 ]
Boriani, Stefano [12 ]
Bettegowda, Chetan [5 ]
Laufer, Ilya [13 ]
Gokaslan, Ziya L. [14 ,15 ]
Fisher, Charles G. [1 ]
机构
[1] Univ British Columbia, Vancouver Gen Hosp, Dept Orthopaed, Div Spine Surg, Vancouver, BC, Canada
[2] Univ Med Ctr Utrecht, Dept Orthoped, Utrecht, Netherlands
[3] Univ Toronto, Sunnybrook Odette Canc Ctr, Dept Radiat Oncol, Toronto, ON, Canada
[4] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA
[5] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA
[6] Univ Penn, Hosp Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA
[7] McGill Univ, Montreal Gen Hosp, Div Surg, Montreal, PQ, Canada
[8] Buda Hlth Ctr, Natl Ctr Spinal Disorders, Budapest, Hungary
[9] Univ Toronto, Toronto Western Hosp, Dept Surg, Div Neurosurg, Toronto, ON, Canada
[10] Mayo Clin, Dept Neurosurg, Rochester, MN USA
[11] Univ Kansas, Univ Kansas Hosp, Dept Neurosurg, Kansas City, KS USA
[12] IRCCS Ist Ortoped Galeazzi, Milan, Italy
[13] Mem Sloan Kettering Canc Ctr, Dept Neurosurg, 1275 York Ave, New York, NY 10021 USA
[14] Brown Univ, Dept Neurosurg, Miriam Hosp, Warren Alpert Med Sch, Providence, RI 02912 USA
[15] Brown Univ, Warren Alpert Med Sch, Rhode Isl Hosp, Dept Neurosurg, Providence, RI 02912 USA
关键词
Metastatic spine disease; Health-related quality of life; Life expectancy; Surgical care; PROGNOSTIC SCORING SYSTEMS; QUALITY-OF-LIFE; CANCER CARE; SURGERY; RADIOTHERAPY; OUTCOMES;
D O I
10.1093/neuros/nyz472
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BACKGROUND: Despite our inability to accurately predict survival in many cancer patients, a life expectancy of at least 3 mo is historically necessary to be considered for surgical treatment of spinal metastases. OBJECTIVE: To compare health-related quality of life (HRQOL) in patients surviving < 3 mo after surgical treatment to patients surviving >3 mo to assess the validity of this inclusion criteria. METHODS: Patients who underwent surgery for spinal metastases between August 2013 and May 2017 were retrospectively identified from an international cohort study. HRQOL was evaluated using generic and disease-specific outcome tools at baseline and at 6 and 12 wk postsurgery. The primary outcome was the HRQOL at 6 wk post-treatment measured by the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ). RESULTS: A total of 253 patients were included: 40 patients died within the first 3 mo after surgery and 213 patients survived more than 3 mo. Patients surviving <3 mo after surgery presented with lower baseline performance status. Adjusted analyses for baseline performance status did not reveal a significant difference in HRQOL between both groups at 6 wk post-treatment. No significant difference in patient satisfaction at 6 wk with regard to their treatment could be detected between both groups. CONCLUSION: When controlled for baseline performance status, quality of life 6 wk after surgery for spinal metastasis is independent of survival. To optimize improvement in HRQOL for this patient population, baseline performance status should take priority over expected survival in the surgical decision-making process.
引用
收藏
页码:303 / 311
页数:9
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