Neuroprotection by astrocytes in brain ischemia: Importance of microRNAs

被引：65

作者：

Ouyang, Yi-Bing ^{[1
]}

Xu, Lijun ^{[1
]}

Yue, Sibiao ^{[2
]}

Liu, Siwei ^{[1
]}

Giffard, Rona G. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA

[2] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA

来源：

NEUROSCIENCE LETTERS | 2014年 / 565卷

关键词：

Astrocyte; microRNA; miR-181; miR-29; miR-146a; Cerebral ischemia; REDUCES NEURONAL VULNERABILITY; TRANSIENT FOCAL ISCHEMIA; CEREBRAL-ISCHEMIA; DOWN-REGULATION; CELL-DEATH; EXPRESSION; TARGETS; STROKE; OVEREXPRESSION; INFLAMMATION;

D O I：

10.1016/j.neulet.2013.11.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Astrocytes have been shown to protect neurons and increase their survival in many pathological settings. Manipulating astrocyte functions is thus an important strategy to enhance neuronal survival and improve outcome following cerebral ischemia. Increasing evidence supports the involvement of microRNAs (miRNA), some of them being astrocyte-enriched, in the regulation of cerebral ischemia. This mini review will focus on several recently reported astrocyte-enriched miRNAs (miR-181 and miR-29 families and miR-146a), their validated targets, regional expression and effects on outcome after cerebral ischemia. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：53 / 58

页数：6

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