New drugs for brain tumors? Insights from chemical probing of neural stem cells

被引：27

作者：

Diamandis, Phedias ^{[1
,2
,3
,4
,5
]}

Sacher, Adrian G. ^{[1
,2
,3
]}

Tyers, Mike ^{[4
,5
]}

Dirks, Peter B. ^{[1
,2
,3
,6
,7
]}

机构：

[1] Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Toronto, ON M5G 1X8, Canada

[3] Hosp Sick Children, Program Dev & Stem Cell Biol, Toronto, ON M5G 1X8, Canada

[4] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[5] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

[6] Univ Toronto, Banting Inst, Dept Lab Med & Pathobiol, Fac Med, Toronto, ON M5G 1L5, Canada

[7] Hosp Sick Children, Div Neurosurg, Toronto, ON M5G 1X8, Canada

来源：

MEDICAL HYPOTHESES | 2009年 / 72卷 / 06期

基金：

加拿大健康研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; CORTICAL PROGENITOR CELLS; HIPPOCAMPAL NEUROGENESIS; GLIOBLASTOMA-MULTIFORME; PARKINSONS-DISEASE; SUBVENTRICULAR ZONE; INITIATING CELLS; CANCER; PROLIFERATION; SCHIZOPHRENIA;

D O I：

10.1016/j.mehy.2008.10.034

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The cancer stem cell hypothesis posits a direct relationship between normal neural stem cells (NSCs) and brain tumour stem cells (BTSCs). New insights into human brain turnout biology and treatment should thus emerge from the study of normal NSCs. These parallels have recently been exploited in a chemical genetic screen that identified a broad repertoire of neurotransmission modulators as inhibitors of both NSC and BTSC expansion in vitro. Prompted by these findings, we sought epidemiological support for effects of neuromodulation of brain tumours in vivo. We present observations from data collected from retrospective clinical studies suggesting that patients with a wide variety of neuropsychiatric disorders have decreased brain turnout incidence. We speculate that this reduction may derive from the use of drugs that collaterally affect the normal neural precursor compartment, and thereby limit a population that is suspected to give rise to brain tumours. Standard chronic neuropharmacological interventions in clinical neuropsychiatric care are thus candidates for redeployment as brain cancer therapeutics. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：683 / 687

页数：5

共 60 条

[1] Activation of the GABA(A) receptor inhibits the proliferative effects of bFGF in cortical progenitor cells [J].