Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

被引：398

作者：

Feuerer, Markus ^{[1
]}

Hill, Jonathan A. ^{[1
]}

Mathis, Diane ^{[1
]}

Benoist, Christophe ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 07期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

DE-NOVO DIFFERENTIATION; TGF-BETA; NEGATIVE SELECTION; THYMIC DEVELOPMENT; SELF-TOLERANCE; CUTTING EDGE; TARGET GENES; TREG CELLS; NAIVE-LIKE; REG-CELLS;

D O I：

10.1038/ni.1760

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells (T-reg cells) characterized by expression of the transcription factor Foxp3 play a key role in immune homeostasis. Rather than a monomorphic population strictly determined by Foxp3 as a 'master regulator', the emerging view is one of T-reg cells as a population with many levels of complexity. Several regulatory factors partake in the control of their transcriptional 'signature', with Foxp3 being a key regulator but insufficient and unnecessary to specify all aspects of the lineage. Distinct subphenotypes of Foxp3(+) T-reg cells are found in different anatomical locations. Some subphenotypes specifically control different facets of effector T cell function and, perhaps surprisingly, share transcriptional control elements with the very cells they regulate. This review will focus on these novel aspects of T-reg cell diversity.

引用

页码：689 / 695

页数：7

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