The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3-ones

被引：8
作者：
Zheng, GG [1 ]
Dwoskin, LP [1 ]
Crooks, PA [1 ]
机构：
[1] Univ Kentucky, Coll Pharm, Lexington, KY 40536 USA
来源：
SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 11期
关键词：
tropane analogs; aldol condensation; CNS agents; THF;
D O I：
10.1081/SCC-120037905
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and versatile two-step synthesis of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octane-3-ones, via mono aldol condensation of tropinone with a variety of aryl aldehydes followed by pTsOH-catalyzed dehydration, is described.
引用
收藏
页码：1931 / 1942
页数：12
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