Impact of 5-Aminoorotic Acid and Its Complex with Gallium(III) on the Luminol-Dependent Chemiluminescence in Presence of Sodium Hypochlorite

被引：2

作者：

Todorov, L. ^{[1
]}

Valcheva-Traykova, M. ^{[2
]}

Traykov, T. ^{[2
]}

Kostova, I. ^{[1
]}

机构：

[1] Med Univ Sofia, Fac Pharm, Dept Chem, 2 Dunav Str, BG-1000 Sofia, Bulgaria

[2] Med Univ Sofia, Med Fac, Dept Med Phys & Biophys, 2 Zdrave Str, BG-1431 Sofia, Bulgaria

来源：

10TH JUBILEE CONFERENCE OF THE BALKAN PHYSICAL UNION | 2019年 / 2075卷

关键词：

HYDROGEN-PEROXIDE; MECHANISMS;

D O I：

10.1063/1.5091369

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The biological activity of hypochlorite is associated with aggressive oxidative interactions with a variety of functional groups leading to oxidative stress in biological systems. Gallium(III) is a well known anticancer agent. Its complex (GaAOA) with 5-aminoorotic acid (HAOA) exhibits antioxidant activity. The aim of the current study is to establish the impact of HAOA and GaAOA on the luminol-dependent chemiluminescence (LDCL) in presence of sodium hypochlorite (NaOCl). A concentration dependent decrease of LDCL is observed in the presence of both investigated substances. At equimolar concentrations, GaAOA demonstrates more potent antioxidant activity. Spectral data indicates that an interaction between hypochlorite and the amino-group of the ligand takes place, contributing to the antioxidant effect of HAOA and its Ga(III) complex.

引用

页数：6

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