Synthesis of drim-8(9)-en-7-one, drima-5,8(9)-dien-7-one, and their 11,12-dibromo derivatives from norambreinolide

被引：13

作者：

Koltsa, MN ^{[1
]}

Mironov, GN ^{[1
]}

Malinovskii, ST ^{[1
]}

Vlad, PF ^{[1
]}

机构：

[1] MOLDAVIAN ACAD SCI,INST CHEM,KISHINEV 277028,MOLDOVA

来源：

RUSSIAN CHEMICAL BULLETIN | 1996年 / 45卷 / 01期

关键词：

norambreinolide; sesquiterpenoids of drimane series; electrochemical oxidation; bromination; X-ray analysis;

D O I：

10.1007/BF01433763

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method was elaborated for the synthesis of polyfunctional compounds of the drimane series, viz., drim-8(9)-en-7-one, drima-5,8(9)-dien-7-one, and their 11,12-dibromo derivatives, potential intermediates for the synthesis of natural biologically active drimane sesquiterpenoids starting from norambreinolide. The key intermediate of the above drimane compounds is methyl 7-oxo-11-homodrim-8(9)-en-12-oate, prepared by electrochemical oxidation of a mixture of isomeric methyl bicyclohomofamesenoates obtained from norambreinolide.

引用

页码：208 / 214

页数：7

共 14 条

[1] TOBACCO CHEMISTRY .28. STRUCTURE AND SYNTHESIS OF DRIM-8-EN-7-ONE, A NEW TOBACCO CONSTITUENT [J].