Fetal sex specific differences in human placentation: A prospective cohort study

被引：74

作者：

Brown, Z. A. ^{[1
,2
]}

Schalekamp-Timmermans, S. ^{[1
,2
]}

Tiemeier, H. W. ^{[3
,4
]}

Hofman, A. ^{[3
]}

Jaddoe, V. W. V. ^{[1
,3
]}

Steegers, E. A. P. ^{[2
]}

机构：

[1] Erasmus MC, Generat Study Grp R, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Obstet & Gynecol, NL-3000 CA Rotterdam, Netherlands

[3] Erasmus MC, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

[4] Erasmus MC, Dept Psychiat, NL-3000 CA Rotterdam, Netherlands

来源：

PLACENTA | 2014年 / 35卷 / 06期

关键词：

Fetal sex; placental biomarkers; GROWTH-FACTOR; HYPERTENSIVE DISORDERS; PLASMA HOMOCYSTEINE; PREGNANCY; PREECLAMPSIA; HEALTH; GESTATION; CHILDREN; ASTHMA; BLOOD;

D O I：

10.1016/j.placenta.2014.03.014

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Introduction: Our objective was to assess fetal sex specific differences in first trimester placental biomarkers of both physiological and pathological pregnancies and their interaction with environmental influences. This study is embedded in the Generation R Study, a prospective cohort study. Methods: Only live singleton births were included. Linear regression was performed to assess the effect of sex on first trimester placental biomarkers. Interaction analyses were performed to assess interaction of fetal sex with environmental influences. First trimester soluble fms-like tyrosine kinase (s-Flt1), placental growth factor (PLGF), plasminogen activator inhibitor (PAI-2) and homocysteine levels were assessed. Results: Significant fetal sex specific differences in placental biomarkers were observed. S-Flt1, PAI-2 and PLGF log transformated concentrations were 0.08 ng/mL (95% CI 0.05; 0.11), 0.07 ng/mL (95% Cl 0.06; 0.09) and 0.04 pg/mL (95% CI 0.01; 0.06) higher in case of female as compared to male placentas. In pregnancies complicated by pre-eclampsia (PE), preterm birth (PTB) or a newborn being small for gestational age (SGA) no fetal sex specific differences were observed. Interaction analyses suggest that concentrations of s-Flt1, PLGF and PAI-2 decrease in male placentas in the case of hyperhomocysteinemia but remain equal in female placentas. Discussion: Fetal sex affects early placentation processes with discrepancies regarding pregnancies complicated by PE, PTB or a newborn being SGA. This suggests that other mechanisms causing these complications may dominate the fetal sex effect. The differences concerning homocysteine suggest that fetal sex dependent placental gene environment interactions exist. Conclusion: Fetal sex specific differences in placental biomarkers exist. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：359 / 364

页数：6

共 35 条

[11] Angiogenic and Fibrinolytic Factors in Blood During the First Half of Pregnancy and Adverse Pregnancy Outcomes [J].

Coolman, Marianne ;

Timmermans, Sarah ;

de Groot, Christianne J. M. ;

Russcher, Henk ;

Lindemans, Jan ;

Hofman, Albert ;

Geurts-Moespot, Anneke J. ;

Sweep, Fred C. G. J. ;

Jaddoe, Vincent V. W. ;

Steegers, Eric A. P. .

OBSTETRICS AND GYNECOLOGY, 2012, 119 (06) :1190-1200

[12] Medical record validation of maternally reported history of preeclampsia [J].

Coolman, Marianne ;

de Groot, Christianne J. M. ;

Jaddoe, Vincent W. ;

Hofman, Albert ;

Raat, Hein ;

Steegers, Eric A. P. .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 2010, 63 (08) :932-937

[13] Nutritional influences on implantation and placental development [J].

Cross, James C. ;

Mickelson, Lindsay .

NUTRITION REVIEWS, 2006, 64 (05) :S12-S18

[14] Hornocysteine induces trophoblast cell death with apoptotic features [J].

Di Simone, N ;

Maggiano, N ;

Caliandro, D ;

Riccardi, P ;

Evangelista, A ;

Carducci, B ;

Caruso, A .

BIOLOGY OF REPRODUCTION, 2003, 69 (04) :1129-1134

[15] Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans [J].

Fryer, Anthony A. ;

Emes, Richard D. ;

Ismail, Khaled M. K. ;

Haworth, Kim E. ;

Mein, Charles ;

Carroll, William D. ;

Farrell, William E. .

EPIGENETICS, 2011, 6 (01) :86-94

[16] Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics [J].

Gabory, Anne ;

Roseboom, Tessa J. ;

Moore, Tom ;

Moore, Lorna G. ;

Junien, Claudine .

BIOLOGY OF SEX DIFFERENCES, 2013, 4

[17] Maternal serum sFIt1 concentration is an early and reliable predictive marker of preeclampsia [J].

Hertig, A ;

Berkane, N ;

Lefevre, G ;

Toumi, K ;

Marti, HP ;

Capeau, J ;

Uzan, S ;

Rondeau, E .

CLINICAL CHEMISTRY, 2004, 50 (09) :1702-1703

[18] Release and complex formation of soluble VEGFR-1 from endothelial cells and biological fluids [J].

Hornig, C ;

Barleon, B ;

Ahmad, S ;

Vuorela, P ;

Ahmed, A ;

Weich, HA .

LABORATORY INVESTIGATION, 2000, 80 (04) :443-454

[19] The Generation R Study Biobank: a resource for epidemiological studies in children and their parents [J].

Jaddoe, Vincent W. V. ;

Bakker, Rachel ;

van Duijn, Cock M. ;

van der Heijden, Albert J. ;

Lindemans, Jan ;

Mackenbach, Johan P. ;

Moll, Henriette A. ;

Steegers, Eric A. P. ;

Tiemeier, Henning ;

Uitterlinden, Andre G. ;

Verhulst, Frank C. ;

Hofman, Albert .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2007, 22 (12) :917-923

[20] The Generation R Study: design and cohort update 2012 [J].

Jaddoe, Vincent W. V. ;

van Duijn, Cornelia M. ;

Franco, Oscar H. ;

van der Heijden, Albert J. ;

van Ijzendoorn, Marinus H. ;

de Jongste, Johan C. ;

van der Lugt, Aad ;

Mackenbach, Johan P. ;

Moll, Henriette A. ;

Raat, Hein ;

Rivadeneira, Fernando ;

Steegers, Eric A. P. ;

Tiemeier, Henning ;

Uitterlinden, Andre G. ;

Verhulst, Frank C. ;

Hofman, Albert .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2012, 27 (09) :739-756

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