Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

被引：157

作者：

Paliogiannis, Panagiotis ^{[1
]}

Fois, Alessandro G. ^{[1
,2
]}

Sotgia, Salvatore ^{[3
]}

Mangoni, Arduino A. ^{[4
]}

Zinellu, Elisabetta ^{[1
,2
]}

Pirina, Pietro ^{[1
,2
]}

Negri, Silvia ^{[1
,2
]}

Carru, Ciriaco ^{[3
]}

Zinellu, Angelo ^{[3
]}

机构：

[1] Univ Sassari, Dept Clin & Expt Med, Via Oriani Alfredo 12, I-07100 Sassari, SS, Italy

[2] Univ Hosp Sassari AOU, Dept Resp Dis, Sassari, Italy

[3] Univ Sassari, Dept Biomed Sci, Sassari, Italy

[4] Flinders Univ S Australia, Dept Clin Pharmacol, Coll Med & Publ Hlth, Adelaide, SA, Australia

来源：

EUROPEAN RESPIRATORY REVIEW | 2018年 / 27卷 / 147期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; POOR PROGNOSTIC-FACTOR; NEUTROPHIL/LYMPHOCYTE RATIO; ELEVATED NEUTROPHIL; ACUTE EXACERBATION; MORTALITY; PATHOGENESIS; INFLAMMATION; PREDICTORS; INFECTION;

D O I：

10.1183/16000617.0113-2017

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.

引用

页数：10

共 62 条

[1] Characterisation of COPD heterogeneity in the ECLIPSE cohort [J].

Agusti, Alvar ;

Calverley, Peter M. A. ;

Celli, Bartolome ;

Coxson, Harvey O. ;

Edwards, Lisa D. ;

Lomas, David A. ;

MacNee, William ;

Miller, Bruce E. ;

Rennard, Steve ;

Silverman, Edwin K. ;

Tal-Singer, Ruth ;

Wouters, Emiel ;

Yates, Julie C. ;

Vestbo, Jorgen .

RESPIRATORY RESEARCH, 2010, 11

[2] Myeloperoxidase as a marker of increasing systemic inflammation in smokers without severe airway symptoms [J].

Andelid, Kristina ;

Bake, Bjorn ;

Rak, Sabina ;

Linden, Anders ;

Rosengren, Annika ;

Ekberg-Jansson, Ann .

RESPIRATORY MEDICINE, 2007, 101 (05) :888-895

[3] Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography [J].

Arbel, Yaron ;

Finkelstein, Ariel ;

Halkin, Amir ;

Birati, Edo Y. ;

Revivo, Miri ;

Zuzut, Meital ;

Shevach, Ayala ;

Berliner, Shlomo ;

Herz, Itzhak ;

Keren, Gad ;

Banai, Shmuel .

ATHEROSCLEROSIS, 2012, 225 (02) :456-460

[4]

Arisoy A, 2015, ACTA MEDICA MEDITERR, V31, P343

[5] Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting Short- and Long-Term Mortality in Breast Cancer Patients [J].

Azab, Basem ;

Bhatt, Vijaya R. ;

Phookan, Jaya ;

Murukutla, Srujitha ;

Kohn, Nina ;

Terjanian, Terenig ;

Widmann, Warren D. .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (01) :217-224

[6] The Predictive Role of Neutrophil to Lymphocyte ratio in Chronic Obstructive Pulmonary Disease [J].

Bilir, Bulent ;

Altintas, Nejat ;

Aydin, Murat ;

Oran, Mustafa ;

Ozsu, Savas ;

Tutar, Umit .

EUROPEAN JOURNAL OF GENERAL MEDICINE, 2016, 13 (02) :105-110

[7] Neutrophils, from Marrow to Microbes [J].

Borregaard, Niels .

IMMUNITY, 2010, 33 (05) :657-670

[8] Chronic Obstructive Pulmonary Disease 1 New insights into the immunology of chronic obstructive pulmonary disease [J].

Brusselle, Guy G. ;

Joos, Guy F. ;

Bracke, Ken R. .

LANCET, 2011, 378 (9795) :1015-1026

[9] Global and regional trends in COPD mortality, 1990-2010 [J].

Burney, Peter G. J. ;

Patel, Jaymini ;

Newson, Roger ;

Minelli, Cosetta ;

Naghavi, Mohsen .

EUROPEAN RESPIRATORY JOURNAL, 2015, 45 (05) :1239-1247

[10] Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention [J].

Duffy, BK ;

Gurm, HS ;

Rajagopal, V ;

Gupta, R ;

Ellis, SG ;

Bhatt, DL .

AMERICAN JOURNAL OF CARDIOLOGY, 2006, 97 (07) :993-996

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