Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

被引：89

作者：

Krata, Natalia ^{[1
]}

Zagozdzon, Radoslaw ^{[1
,2
,3
]}

Foroncewicz, Bartosz ^{[1
]}

Mucha, Krzysztof ^{[1
,2
]}

机构：

[1] Med Univ Warsaw, Dept Immunol Transplantol & Internal Dis, Nowogrodzka 59, PL-02006 Warsaw, Poland

[2] Polish Acad Sci, Inst Biochem & Biophys, Warsaw, Poland

[3] Med Univ Warsaw, Dept Clin Immunol, Warsaw, Poland

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2018年 / 66卷 / 03期

基金：

欧盟地平线“2020”;

关键词：

Oxidative stress; Biomarkers; Chronic kidney disease; GELATINASE-ASSOCIATED LIPOCALIN; PERITONEAL-DIALYSIS PATIENTS; CHRONIC-RENAL-FAILURE; ALPHA-KETOGLUTARATE; N-ACETYLCYSTEINE; VITAMIN-E; IN-VIVO; MAINTENANCE HEMODIALYSIS; ANTIOXIDANT CAPACITY; NONDIABETIC PATIENTS;

D O I：

10.1007/s00005-017-0496-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism's cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In nephrology, researchers are looking for alternative methods replacing the renal biopsy in patients with suspicion of chronic kidney disease (CKD). Currently, CKD is a frequent health problem in world population, which can lead to progressive loss of kidney function and eventually to end-stage renal disease. The course of CKD depends on the primary disease. It is assumed that one of the factors influencing the course of CKD might be OS. In the current work, we review whether monitoring the OS-associated biomarkers in nephrology patients can support the decision-making process regarding diagnosis, prognostication and treatment initiation.

引用

页码：211 / 220

页数：10

共 100 条

[1]

Annuk M, 2005, J NEPHROL, V18, P721

[2]

[Anonymous], OXID MED CELL LONGEV

[3] Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating γ-glutamyl-cysteinyl ligase and glutathione reductase [J].

Arab, K ;

Rossary, A ;

Flourié, F ;

Tourneur, Y ;

Steghens, JP .

BRITISH JOURNAL OF NUTRITION, 2006, 95 (01) :18-26

[4] Association between Biomarkers of Carbonyl Stress with Increased Systemic Inflammatory Response in Different Stages of Chronic Kidney Disease and after Renal Transplantation [J].

Aveles, Paulo R. ;

Criminacio, Ciro R. ;

Goncalves, Simone ;

Bignelli, Alexandre T. ;

Claro, Ligia Maria ;

Siqueira, Sergio S. ;

Nakao, Lia S. ;

Pecoits-Filho, Roberto .

NEPHRON CLINICAL PRACTICE, 2010, 116 (04) :C294-C299

[5] Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2′-deoxyguanosine [J].

Barregard, Lars ;

Moller, Peter ;

Henriksen, Trine ;

Mistry, Vilas ;

Koppen, Gudrun ;

Rossner, Pavel, Jr. ;

Sram, Radim J. ;

Weimann, Allan ;

Poulsen, Henrik E. ;

Nataf, Robert ;

Andreoli, Roberta ;

Manini, Paola ;

Marczylo, Tim ;

Lam, Patricia ;

Evans, Mark D. ;

Kasai, Hiroshi ;

Kawai, Kazuaki ;

Li, Yun-Shan ;

Sakai, Kazuo ;

Singh, Rajinder ;

Teichert, Friederike ;

Farmer, Peter B. ;

Rozalski, Rafal ;

Gackowski, Daniel ;

Siomek, Agnieszka ;

Saez, Guillermo T. ;

Cerda, Concha ;

Broberg, Karin ;

Lindh, Christian ;

Hossain, Mohammad Bakhtiar ;

Haghdoost, Siamak ;

Hu, Chiung-Wen ;

Chao, Mu-Rong ;

Wu, Kuen-Yuh ;

Orhan, Hilmi ;

Senduran, Nilufer ;

Smith, Raymond J. ;

Santella, Regina M. ;

Su, Yali ;

Cortez, Czarina ;

Yeh, Susan ;

Olinski, Ryszard ;

Loft, Steffen ;

Cooke, Marcus S. .

ANTIOXIDANTS & REDOX SIGNALING, 2013, 18 (18) :2377-2391

[6] Calcium ketoglutarate versus calcium acetate for treatment of hyperphosphataemia in patients on maintenance haemodialysis:: a crossover study [J].

Birck, R ;

Zimmermann, E ;

Wassmer, S ;

Nowack, R ;

van der Woude, FJ .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (06) :1475-1479

[7] Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial [J].

Boaz, M ;

Smetana, S ;

Weinstein, T ;

Matas, Z ;

Gafter, U ;

Iaina, A ;

Knecht, A ;

Weissgarten, Y ;

Brunner, D ;

Fainaru, M ;

Green, MS .

LANCET, 2000, 356 (9237) :1213-1218

[8] Antibody-based proteomics: fast-tracking molecular diagnostics in oncology [J].

Brennan, Donal J. ;

O'Connor, Darran P. ;

Rexhepaj, Elton ;

Ponten, Fredrik ;

Gallagher, William M. .

NATURE REVIEWS CANCER, 2010, 10 (09) :605-617

[9] CKD Prevalence Varies across the European General Population [J].

Bruck, Katharina ;

Stel, Vianda S. ;

Gambaro, Giovanni ;

HaIlan, Stein ;

Volzke, Henry ;

Arnlov, Johan ;

Kastarinen, Mika ;

Guessous, Idris ;

Vinhas, Jose ;

Stengel, Benedicte ;

Brenner, Hermann ;

Chudek, Jerzy ;

Romundstad, Solfrid ;

Tomson, Charles ;

Otero Gonzalez, Alfonso ;

Bello, Aminu K. ;

Ferrieres, Jean ;

Palmieri, Luigi ;

Browne, Gemma ;

Capuano, Vincenzo ;

Van Biesen, Wim ;

Zoccali, Carmine ;

Gansevoort, Ron ;

Navis, Gerjan ;

Rothenbacher, Dietrich ;

Ferraro, Pietro Manuel ;

Nitsch, Dorothea ;

Wanner, Christoph ;

Jager, Kitty J. ;

Consortium, European C. K. D. Burden .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (07) :2135-2147

[10] Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease [J].

Cachofeiro, Victoria ;

Goicochea, Marian ;

Garcia de Vinuesa, Soledad ;

Oubina, Pilar ;

Lahera, Vicente ;

Luno, Jose .

KIDNEY INTERNATIONAL, 2008, 74 :S4-S9

← 1 2 3 4 5 6 7 8 9 10 →