Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 diabetes mellitus

被引：67

作者：

Jiang, Shuang ^{[1
,3
]}

Ren, Dayong ^{[2
]}

Li, Jianrui ^{[4
]}

Yuan, Guangxin ^{[1
,5
]}

Li, Hongyu ^{[1
,5
]}

Xu, Guangyu ^{[1
]}

Han, Xiao ^{[1
]}

Du, Peige ^{[1
]}

An, Liping ^{[1
]}

机构：

[1] Beihua Univ, Coll Pharm, Jilin 132013, Peoples R China

[2] Jilin Agr Univ, Coll Food Sci & Engn, Changchun 130117, Jilin, Peoples R China

[3] Changchun Univ Chinese Med, Coll Basic Med Sci, Changchun 130117, Jilin, Peoples R China

[4] Changchun Univ Chinese Med, Dept Personnel, Changchun 130117, Jilin, Peoples R China

[5] Biol Macromol Funct Dev & Applicat Engn Lab, Jilin 132013, Peoples R China

来源：

FITOTERAPIA | 2014年 / 95卷

关键词：

Compound K; Hyperglycemia; Insulin resistance; SIGNALING PATHWAYS; GINSENG SAPONIN; DIET; GINSENOSIDES; METABOLITE; STREPTOZOTOCIN; COMBINATION; ACTIVATION; APOPTOSIS; TARGETS;

D O I：

10.1016/j.fitote.2014.02.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Compound K (CM) is a final metabolite of panaxadiol ginsenosides from Panax ginseng. Although anti-diabetic activity of CM has been reported in recent years, the molecular mechanism of CM in the treatment of diabetes mellitus remains unclear. In the present investigation, we established a rat model of type 2 diabetes mellitus (T2DM) with insulin resistance using high-fat diet (HFD) and streptozotocin (STZ), and attempted to verify more details and exact mechanisms in the treatment of T2DM. CM was administered orally at three doses 1300, 100 and 30 mg/kg bodyweight (b.w.)] to the diabetic rats. Bodyweight, food-intake, fasting blood glucose (FBG), fasting serum insulin (FINS), insulin sensitivity (ISI), total glycerin (TG), total cholesterol (TC), as well as oral glucose tolerance test (OGTT) were evaluated in normal and diabetic rats. According to our results, CM could improve bodyweight and food-intake of diabetic rats. CM exhibited dose-dependent reduction of FBG, TG and TC of diabetic rats. CM treatment also enhanced FINS and ISI. Meanwhile, the glucose tolerance observed in the present study was improved significantly by CM. It is concluded from the results that CM may have improving effects on hyperglycemia and insulin resistance of diabetic rats. Furthermore, research showed that CM could promote the expression of InsR, IRS1, PI3Kp85, pAkt and Glut4 in skeletal muscle tissue of diabetic rats. These results indicate that the hypoglycemic activity of CM is mediated by improvement of insulin sensitivity, which is closely related to PI3K/Akt signaling pathway. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：58 / 64

页数：7

共 38 条

[1] Ginseng pharmacology - Multiple constituents and multiple actions [J].

Attele, AS ;

Wu, JA ;

Yuan, CS .

BIOCHEMICAL PHARMACOLOGY, 1999, 58 (11) :1685-1693

[2] TYPE 2 DIABETES MELLITUS IN 2010 Individualizing treatment targets in diabetes care [J].

Buse, John B. .

NATURE REVIEWS ENDOCRINOLOGY, 2011, 7 (02) :67-68

[3] Oligofructose protects against the hypertriglyceridemic and pro-oxidative effects of a high fructose diet in rats [J].

Busserolles, J ;

Gueux, E ;

Rock, E ;

Demigné, C ;

Mazur, A ;

Rayssiguier, Y .

JOURNAL OF NUTRITION, 2003, 133 (06) :1903-1908

[4] Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats [J].

Busserolles, J ;

Rock, E ;

Gueux, E ;

Mazur, A ;

Grolier, P ;

Rayssiguier, Y .

BRITISH JOURNAL OF NUTRITION, 2002, 87 (04) :337-342

[5] Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells [J].

Cho, Sung-Hee ;

Chung, Kyung-Sook ;

Choi, Jung-Hye ;

Kim, Dong-Hyun ;

Lee, Kyung-Tae .

BMC CANCER, 2009, 9

[6] Ginsenosides compound K and Rh2 inhibit tumor necrosis factor-α-induced activation of the NF-κB and JNK pathways in human astroglial cells [J].

Choi, Kyungsun ;

Kim, Myungsun ;

Ryu, Jeonghee ;

Choi, Chulhee .

NEUROSCIENCE LETTERS, 2007, 421 (01) :37-41

[7] Proapoptotic Ginsenosides Compound K and Rh2 Enhance Fas-induced Cell Death of Human Astrocytoma Cells Through Distinct Apoptotic Signaling Pathways [J].

Choi, Kyungsun ;

Choi, Chulhee .

CANCER RESEARCH AND TREATMENT, 2009, 41 (01) :36-44

[8] Molecular mechanisms of insulin resistance:: Serine phosphorylation of insulin receptor substrate-1 and increased expression of p85α -: The two sides of a coin [J].

Draznin, Boris .

DIABETES, 2006, 55 (08) :2392-2397

[9] GLUCOSE-TRANSPORT AND NIDDM [J].

GARVEY, WT .

DIABETES CARE, 1992, 15 (03) :396-417

[10] Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice [J].

Han, Gi Cheol ;

Ko, Sung Kwon ;

Sung, Jong Hwan ;

Chung, Sung Hyun .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (26) :10641-10648

← 1 2 3 4 →