Enantiomeric separation of diols and beta-amino alcohols by chiral stationary phase derived from (R,R)-tartramide

被引：17
作者：
Machida, Y
Nishi, H
Nakamura, K
Nakai, H
Sato, T
机构：
[1] Analytical Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka 532, 16-89, Kashima 3-chome, Yodogawa-ku
来源：
JOURNAL OF CHROMATOGRAPHY A | 1997年 / 757卷 / 1-2期
关键词：
enantiomer separation; chiral stationary phases; LC; diols; beta-amino alcohols;
D O I：
10.1016/S0021-9673(96)00658-9
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel chiral stationary phase (CSP) having a (R,R)-tartramide derivative as a chiral moiety was synthesized. This CSP showed good chiral recognition for 1,2-diols, bi-beta-naphthol and beta-amino alcohols (beta-blockers) without any derivatization. The driving force of enantiomeric separation was assumed to be the dual hydrogen-bonding association and pi-pi interaction between the solute enantiomers and the chiral moiety of CSP.
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页码：73 / 79
页数：7
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