Heightened Cytotoxic Responses and Impaired Biogenesis Contribute to Early Pathogenesis in the Oral Mucosa of Simian Immunodeficiency Virus-Infected Rhesus Macaques

被引：7
|
作者：
George, Michael D. [1 ]
Verhoeven, David [1 ]
Sankaran, Sumathi [1 ]
Glavan, Tiffany [1 ]
Reay, Elizabeth [1 ]
Dandekar, Satya [1 ]
机构：
[1] Univ Calif Davis, Sch Med, Dept Med Microbiol, Davis, CA 95616 USA
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2009年 / 16卷 / 02期
基金：
美国国家卫生研究院;
关键词：
T-CELL RESTORATION; SIV INFECTION; ANTIRETROVIRAL THERAPY; IMMUNE-RESPONSE; GUT MUCOSA; CD4(+); LYMPHOCYTES; EXPRESSION; DEPLETION; MONKEYS;
D O I：
10.1128/CVI.00265-08
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4(+) T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.
引用
收藏
页码：277 / 281
页数：5
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