Heightened Cytotoxic Responses and Impaired Biogenesis Contribute to Early Pathogenesis in the Oral Mucosa of Simian Immunodeficiency Virus-Infected Rhesus Macaques

被引：7

作者：

George, Michael D. ^{[1
]}

Verhoeven, David ^{[1
]}

Sankaran, Sumathi ^{[1
]}

Glavan, Tiffany ^{[1
]}

Reay, Elizabeth ^{[1
]}

Dandekar, Satya ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Med, Dept Med Microbiol, Davis, CA 95616 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2009年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

T-CELL RESTORATION; SIV INFECTION; ANTIRETROVIRAL THERAPY; IMMUNE-RESPONSE; GUT MUCOSA; CD4(+); LYMPHOCYTES; EXPRESSION; DEPLETION; MONKEYS;

D O I：

10.1128/CVI.00265-08

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4(+) T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.

引用

页码：277 / 281

页数：5

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