共 109 条
G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there?
被引:291
作者:

Chini, B
论文数: 0 引用数: 0
h-index: 0
机构:
CNR, Inst Neurosci, Cellular & Mol Pharmacol Sect, Milan, Italy CNR, Inst Neurosci, Cellular & Mol Pharmacol Sect, Milan, Italy

Parenti, M
论文数: 0 引用数: 0
h-index: 0
机构: CNR, Inst Neurosci, Cellular & Mol Pharmacol Sect, Milan, Italy
机构:
[1] CNR, Inst Neurosci, Cellular & Mol Pharmacol Sect, Milan, Italy
[2] Univ Milan, Dept Expt & Environm Med & Med Biotechnol, Monza, Italy
关键词:
D O I:
10.1677/jme.0.0320325
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
This review describes the advances in our understanding of the role of G-protein coupled receptor (GPCR) localisation in membrane microdomains known as lipid rafts and caveolae. The growing interest in these specialised regions is due to the recognition that they are involved in the regulation of a number of cell functions, including the fine-tuning of various signalling molecules. As a number of GPCRs have been found to be enriched in lipid rafts and/or caveolae by means of different experimental approaches, we first discuss the pitfalls and uncertainties related to the use of these different procedures. We then analyse the addressing signals that drive and/or stabilise GPCRs in lipid rafts and caveolae, and explore the role of rafts/caveolae in regulating GPCR trafficking, particularly in receptor exo- and endocytosis. Finally, we review the growing evidence that lipid rafts and caveolae participate in the regulation of GPCR signalling by affecting both signalling selectivity and coupling efficacy.
引用
收藏
页码:325 / 338
页数:14
相关论文
共 109 条
- [1] The γ-aminobutyric acid receptor B, but not the metabotropic glutamate receptor type-1, associates with lipid rafts in the rat cerebellum[J]. JOURNAL OF NEUROCHEMISTRY, 2001, 79 (04) : 787 - 795Becher, A论文数: 0 引用数: 0 h-index: 0机构: MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, EnglandWhite, JH论文数: 0 引用数: 0 h-index: 0机构: MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, EnglandMcIlhinney, RAJ论文数: 0 引用数: 0 h-index: 0机构: MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, England
- [2] Regulation and intracellular trafficking pathways of the endothelin receptors[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) : 17596 - 17604Bremnes, T论文数: 0 引用数: 0 h-index: 0机构: Univ Oslo, Natl Hosp Norway, Cardiovasc Res Ctr, MSD,Inst Surg Res, N-0027 Oslo, NorwayPaasche, JD论文数: 0 引用数: 0 h-index: 0机构: Univ Oslo, Natl Hosp Norway, Cardiovasc Res Ctr, MSD,Inst Surg Res, N-0027 Oslo, NorwayMehlum, A论文数: 0 引用数: 0 h-index: 0机构: Univ Oslo, Natl Hosp Norway, Cardiovasc Res Ctr, MSD,Inst Surg Res, N-0027 Oslo, NorwaySandberg, C论文数: 0 引用数: 0 h-index: 0机构: Univ Oslo, Natl Hosp Norway, Cardiovasc Res Ctr, MSD,Inst Surg Res, N-0027 Oslo, NorwayBremnes, B论文数: 0 引用数: 0 h-index: 0机构: Univ Oslo, Natl Hosp Norway, Cardiovasc Res Ctr, MSD,Inst Surg Res, N-0027 Oslo, NorwayAttramadal, H论文数: 0 引用数: 0 h-index: 0机构: Univ Oslo, Natl Hosp Norway, Cardiovasc Res Ctr, MSD,Inst Surg Res, N-0027 Oslo, Norway
- [3] Functions of lipid rafts in biological membranes[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 : 111 - 136Brown, DA论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USALondon, E论文数: 0 引用数: 0 h-index: 0机构: SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA
- [4] SIGNAL-TRANSDUCTION OF A G-PROTEIN-COUPLED RECEPTOR IN CAVEOLAE - COLOCALIZATION OF ENDOTHELIN AND ITS RECEPTOR WITH CAVEOLIN[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) : 11728 - 11732CHUN, MY论文数: 0 引用数: 0 h-index: 0机构: WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142LIYANAGE, UK论文数: 0 引用数: 0 h-index: 0机构: WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142LISANTI, MP论文数: 0 引用数: 0 h-index: 0机构: WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142LODISH, HF论文数: 0 引用数: 0 h-index: 0机构: WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142
- [5] Regulated portals of entry into the cell[J]. NATURE, 2003, 422 (6927) : 37 - 44Conner, SD论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USASchmid, SL论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
- [6] Identification of peptide and protein ligands for the caveolin-scaffolding domain - Implications for the interaction of caveolin with caveolae-associated proteins[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) : 6525 - 6533Couet, J论文数: 0 引用数: 0 h-index: 0机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE CTR 9, CAMBRIDGE, MA 02142 USALi, SW论文数: 0 引用数: 0 h-index: 0机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE CTR 9, CAMBRIDGE, MA 02142 USAOkamoto, T论文数: 0 引用数: 0 h-index: 0机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE CTR 9, CAMBRIDGE, MA 02142 USAIkezu, T论文数: 0 引用数: 0 h-index: 0机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE CTR 9, CAMBRIDGE, MA 02142 USALisanti, MP论文数: 0 引用数: 0 h-index: 0机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE CTR 9, CAMBRIDGE, MA 02142 USA
- [7] Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling[J]. EMBO JOURNAL, 2000, 19 (16) : 4272 - 4280Dessy, C论文数: 0 引用数: 0 h-index: 0机构: Univ Catholique Louvain, Dept Med, Unit Pharmacol & Therapeut, B-1200 Brussels, BelgiumKelly, RA论文数: 0 引用数: 0 h-index: 0机构: Univ Catholique Louvain, Dept Med, Unit Pharmacol & Therapeut, B-1200 Brussels, BelgiumBalligand, JL论文数: 0 引用数: 0 h-index: 0机构: Univ Catholique Louvain, Dept Med, Unit Pharmacol & Therapeut, B-1200 Brussels, BelgiumFeron, O论文数: 0 引用数: 0 h-index: 0机构: Univ Catholique Louvain, Dept Med, Unit Pharmacol & Therapeut, B-1200 Brussels, Belgium
- [8] Bradykinin sequesters B2 bradykinin receptors and the receptor-coupled G alpha subunits G alpha(q) and G alpha(i) in caveolae in DDT1 MF-2 smooth muscle cells[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (28) : 17858 - 17866deWeerd, WFC论文数: 0 引用数: 0 h-index: 0机构: UNIV TEXAS, HLTH SCI CTR, DEPT BIOCHEM, SAN ANTONIO, TX 78284 USA UNIV TEXAS, HLTH SCI CTR, DEPT BIOCHEM, SAN ANTONIO, TX 78284 USALeebLundberg, LMF论文数: 0 引用数: 0 h-index: 0机构: UNIV TEXAS, HLTH SCI CTR, DEPT BIOCHEM, SAN ANTONIO, TX 78284 USA UNIV TEXAS, HLTH SCI CTR, DEPT BIOCHEM, SAN ANTONIO, TX 78284 USA
- [9] CAVEOLIN IS PALMITOYLATED ON MULTIPLE CYSTEINE RESIDUES - PALMITOYLATION IS NOT NECESSARY FOR LOCALIZATION OF CAVEOLIN TO CAVEOLAE[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (12) : 6838 - 6842DIETZEN, DJ论文数: 0 引用数: 0 h-index: 0机构: WASHINGTON UNIV, SCH MED, DEPT PATHOL, DIV LAB MED, ST LOUIS, MO 63110 USAHASTINGS, WR论文数: 0 引用数: 0 h-index: 0机构: WASHINGTON UNIV, SCH MED, DEPT PATHOL, DIV LAB MED, ST LOUIS, MO 63110 USALUBLIN, DM论文数: 0 引用数: 0 h-index: 0机构: WASHINGTON UNIV, SCH MED, DEPT PATHOL, DIV LAB MED, ST LOUIS, MO 63110 USA
- [10] Cholesterol depletion disrupts caveolae and differentially impairs agonist-induced arterial contraction[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (08) : 1267 - 1272Dreja, K论文数: 0 引用数: 0 h-index: 0机构: Lund Univ, Dept Physiol Sci, S-22184 Lund, SwedenVoldstedlund, M论文数: 0 引用数: 0 h-index: 0机构: Lund Univ, Dept Physiol Sci, S-22184 Lund, SwedenVinten, J论文数: 0 引用数: 0 h-index: 0机构: Lund Univ, Dept Physiol Sci, S-22184 Lund, SwedenTranum-Jensen, J论文数: 0 引用数: 0 h-index: 0机构: Lund Univ, Dept Physiol Sci, S-22184 Lund, SwedenHellstrand, P论文数: 0 引用数: 0 h-index: 0机构: Lund Univ, Dept Physiol Sci, S-22184 Lund, SwedenSwärd, K论文数: 0 引用数: 0 h-index: 0机构: Lund Univ, Dept Physiol Sci, S-22184 Lund, Sweden