Principles and Applications of Enantioselective Hydroformylation of Terminal Disubstituted Alkenes

被引：55

作者：

Deng, Yuchao ^{[1
,2
]}

Wang, Hui ^{[1
,2
]}

Sun, Yuhan ^{[1
]}

Wang, Xiao ^{[1
,3
,4
]}

机构：

[1] Chinese Acad Sci, Shanghai Adv Res Inst, CAS Key Lab Low Carbon Convers Sci & Engn, Shanghai 201210, Peoples R China

[2] Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China

[3] Harvard Univ, Sch Med, Harvard NeuroDiscovery Ctr, Cambridge, MA 02139 USA

[4] Brigham & Womens Hosp, Cambridge, MA 02139 USA

来源：

ACS Catalysis | 2015年 / 5卷 / 11期

关键词：

hydroformylation; homogeneous catalysis; oxo products; terminal disubstituted alkene; enantioselectivity; chiral pocket; linear aldehyde; regioselectivity; CATALYZED ASYMMETRIC HYDROFORMYLATION; PHOSPHINE-PHOSPHITE LIGANDS; RHODIUM(I) COMPLEXES; DIPHOSPHITE LIGANDS; DIASTEREOSELECTIVE HYDROFORMYLATION; 1,1-DISUBSTITUTED ALKENES; DIAZAPHOSPHOLANE LIGANDS; UNSATURATED ESTERS; ALLYLIC ALCOHOLS; ARYL ALKENES;

D O I：

10.1021/acscatal.5b01300

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Asymmetric hydroformylation has been primarily focused on monosubstituted and 1,2-disubstituted alkenes. In this Perspective, progress in enantioselective hydroformylation of terminal disubstituted alkenes is outlined on the basis of different categories of substrates. The origins of the commonly observed low degree of enantioselectivity are discussed. Examples with unconventional regioselectivity are also rationalized.

引用

页码：6828 / 6837

页数：10

共 80 条

[1] Immobilized Bisdiazaphospholane Catalysts for Asymmetric Hydroformylation [J].