Inflammation and Cancer: IL-6 and STAT3 Complete the Link

被引：469
作者：
Bromberg, Jacqueline [2 ]
Wang, Timothy C. [1 ]
机构：
[1] Columbia Univ, Dept Med, New York, NY 10031 USA
[2] Dept Med, Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
来源：
CANCER CELL | 2009年 / 15卷 / 02期
关键词：
TUMORIGENESIS;
D O I：
10.1016/j.ccr.2009.01.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：79 / 80
页数：2
相关论文
共 10 条
[1]   gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis [J].
Bollrath, Julia ;
Phesse, Toby J. ;
von Burstin, Vivian A. ;
Putoczki, Tracy ;
Bennecke, Moritz ;
Bateman, Trudie ;
Nebelsiek, Tim ;
Lundgren-May, Therese ;
Canli, Oezge ;
Schwitalla, Sarah ;
Matthews, Vance ;
Schmid, Roland M. ;
Kirchner, Thomas ;
Arkan, Melek C. ;
Ernst, Matthias ;
Greten, Florian R. .
CANCER CELL, 2009, 15 (02) :91-102
[2]   Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis [J].
Chan, KS ;
Sano, S ;
Kiguchi, K ;
Anders, J ;
Komazawa, N ;
Takeda, J ;
DiGiovanni, J .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (05) :720-728
[3]   STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice [J].
Ernst, Matthias ;
Najdovska, Meri ;
Grail, Dianne ;
Lundgren-May, Therese ;
Buchert, Michael ;
Tye, Hazel ;
Matthews, Vance B. ;
Armes, Jane ;
Bhathal, Prithi S. ;
Hughes, Norman R. ;
Marcusson, Eric G. ;
Karras, James G. ;
Na, Songqing ;
Sedgwick, Jonathon D. ;
Hertzog, Paul J. ;
Jenkins, Brendan J. .
JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (05) :1727-1738
[4]   IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer [J].
Greten, FR ;
Eckmann, L ;
Greten, TF ;
Park, JM ;
Li, ZW ;
Egan, LJ ;
Kagnoff, MF ;
Karin, M .
CELL, 2004, 118 (03) :285-296
[5]   IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer [J].
Grivennikov, Sergei ;
Karin, Eliad ;
Terzic, Janos ;
Mucida, Daniel ;
Yu, Guann-Yi ;
Vallabhapurapu, Sivakumar ;
Scheller, Juergen ;
Rose-John, Stefan ;
Cheroutre, Hilde ;
Eckmann, Lars ;
Karin, Michael .
CANCER CELL, 2009, 15 (02) :103-113
[6]   Principles of interleukin (IL)-6-type cytokine signalling and its regulation [J].
Heinrich, PC ;
Behrmann, I ;
Haan, S ;
Hermanns, HM ;
Müller-Newen, G ;
Schaper, F .
BIOCHEMICAL JOURNAL, 2003, 374 (01) :1-20
[7]   Significance of interleukin-6 (IL-6) in breast cancer (review) [J].
Knuepfer, Heike ;
Preiss, Rainer .
BREAST CANCER RESEARCH AND TREATMENT, 2007, 102 (02) :129-135
[8]   IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis [J].
Maeda, S ;
Kamata, H ;
Luo, JL ;
Leffert, H ;
Karin, M .
CELL, 2005, 121 (07) :977-990
[9]   Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production [J].
Naugler, Willscott E. ;
Sakurai, Toshiharu ;
Kim, Sunhwa ;
Maeda, Shin ;
Kim, KyoungHyun ;
Elsharkawy, Ahmed M. ;
Karin, Michael .
SCIENCE, 2007, 317 (5834) :121-124
[10]   The stats of cancer - New molecular targets come of age [J].
Yu, H ;
Jove, R .
NATURE REVIEWS CANCER, 2004, 4 (02) :97-105
1