Intraoperative near-infrared fluorescence imaging of parathyroid adenomas with use of low-dose methylene blue

被引：64

作者：

van der Vorst, Joost R. ^{[1
]}

Schaafsma, Boudewijn E. ^{[1
]}

Verbeek, Floris P. R. ^{[1
]}

Swijnenburg, Rutger-Jan ^{[1
]}

Tummers, Quirijn R. J. G. ^{[1
]}

Hutteman, Merlijn ^{[1
]}

Hamming, Jaap F. ^{[1
]}

Kievit, Job ^{[1
]}

Frangioni, John V. ^{[2
,3
]}

van de Velde, Cornelis J. H. ^{[1
]}

Vahrmeijer, Alexander L. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands

[2] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA

[3] Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Dept Med, Boston, MA 02215 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2014年 / 36卷 / 06期

基金：

美国国家卫生研究院;

关键词：

near-infrared fluorescence imaging; image-guided surgery; hyperparathyroidism; methylene blue; parathyroid adenoma; MINIMALLY INVASIVE PARATHYROIDECTOMY; SURGICAL-MANAGEMENT; IDENTIFICATION; SURGERY;

D O I：

10.1002/hed.23384

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundIntraoperative identification of parathyroid adenomas can be challenging. We hypothesized that low-doses methylene blue (MB) and near-infrared fluorescence (NIRF) imaging could be used to identify parathyroid adenomas intraoperatively. MethodsMB was injected intravenously after exploration at a dose of 0.5 mg/kg into 12 patients who underwent parathyroid surgery. NIRF imaging was performed using the Mini-FLARE imaging system. ResultsIn 10 of 12 patients, histology confirmed a parathyroid adenoma. In 9 of these patients, NIRF could clearly identify the parathyroid adenoma during surgery. Seven of these 9 patients had a positive preoperative Tc-99m-sestamibi single photon emission CT (SPECT) scan. Importantly, in 2 patients, parathyroid adenomas could be identified only using NIRF. ConclusionThis is the first study to show that low-dose MB can be used as NIRF tracer for identification of parathyroid adenomas, and suggests a correlation with preoperative Tc-99m-sestamibi SPECT scanning. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 853-858, 2014

引用

页码：853 / 858

页数：6

共 26 条

[1] A Meta-analysis of Preoperative Localization Techniques for Patients with Primary Hyperparathyroidism [J].

Cheung, Kevin ;

Wang, Tracy S. ;

Farrokhyar, Forough ;

Roman, Sanziana A. ;

Sosa, Julie A. .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (02) :577-583

[2] Intraoperative Multispectral Fluorescence Imaging for the Detection of the Sentinel Lymph Node in Cervical Cancer: A Novel Concept [J].

Crane, Lucia M. A. ;

Themelis, George ;

Pleijhuis, Rick G. ;

Harlaar, Niels J. ;

Sarantopoulos, Athanasios ;

Arts, Henriette J. G. ;

van der Zee, Ate G. J. ;

Vasilis, Ntziachristos ;

van Dam, Gooitzen M. .

MOLECULAR IMAGING AND BIOLOGY, 2011, 13 (05) :1043-1049

[3] METHYLENE BLUE FOR RAPID IDENTIFICATION OF PARATHYROIDS [J].

DUDLEY, NE .

BRITISH MEDICAL JOURNAL, 1971, 3 (5776) :680-&

[4] Minimally invasive radioguided parathyroidectomy [J].

Flynn, MB ;

Bumpous, JM ;

Schill, K ;

McMasters, KM .

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2000, 191 (01) :24-31

[5] New technologies for human cancer imaging [J].

Frangioni, John V. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (24) :4012-4021

[6] Image-Guided Surgery Using Invisible Near-Infrared Light: Fundamentals of Clinical Translation [J].

Gioux, Sylvain ;

Choi, Hak Soo ;

Frangioni, John V. .

MOLECULAR IMAGING, 2010, 9 (05) :237-255

[7] Primary hyperparathyroidism surgical management since the introduction of minimally invasive parathyroidectomy - Mayo Clinic experience [J].

Grant, CS ;

Thompson, G ;

Farley, D ;

van Heerden, J .

ARCHIVES OF SURGERY, 2005, 140 (05) :472-478

[8]

Han N, 2007, AM SURGEON, V73, P820

[9] Intraoperative adjuncts in surgery for primary hyperparathyroidism [J].

Harrison, Barney J. ;

Triponez, Frederic .

LANGENBECKS ARCHIVES OF SURGERY, 2009, 394 (05) :799-809

[10] Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer [J].

Hutteman, Merlijn ;

van der Vorst, Joost R. ;

Gaarenstroom, Katja N. ;

Peters, Alexander A. W. ;

Mieog, J. Sven D. ;

Schaafsma, Boudewijn E. ;

Lowik, Clemens W. G. M. ;

Frangioni, John V. ;

van de Velde, Cornelis J. H. ;

Vahrmeijer, Alexander L. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2012, 206 (01) :89.e1-89.e5

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