Injectable Superparamagnetic Ferrogels for Controlled Release of Hydrophobic Drugs

被引：144

作者：

Qin, Jian ^{[1
]}

Asempah, Isaac ^{[1
]}

Laurent, Sophie ^{[2
,3
]}

Fornara, Andrea ^{[1
]}

Muller, Robert N. ^{[2
,3
]}

Muhammed, Mamoun ^{[1
]}

机构：

[1] Royal Inst Technol, Div Funct Mat, S-16440 Stockholm, Sweden

[2] Univ Mons, Dept Gen Organ & Biomed Chem, NMR, B-7000 Mons, Belgium

[3] Univ Mons, Mol Imaging Lab, B-7000 Mons, Belgium

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 13期

关键词：

BLOCK-COPOLYMER SOLUTIONS; PLURONIC F-127 GELS; MAGNETIC NANOPARTICLES; AQUEOUS-SOLUTION; IN-VITRO; BEHAVIOR; DELIVERY; HYDROGELS; SOLUBILIZATION; NANOCRYSTALS;

D O I：

10.1002/adma.200800764

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A ferrogel for magnetically controlled release of drugs is prepared by integration of superparamagnetic iron oxide nanoparticles and Pluronic F127 gels. The hydrophobic drug indomethacin is loaded in the ferrogel owing to the oil-in-water micellar structure. The characteristic solgel transition property renders the ferrogel an injectable drug carrier that will be, in principle, free from surgical implant procedure.

引用

页码：1354 / 1357

页数：4

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