Immunohistochemical localization of metallothionein in the olfactory pathway of dogs

被引:9
|
作者
Shimada, A
Irie, M
Kojima, S
Kobayashi, K
Yamano, Y
Umemura, T
机构
[1] TOTTORI UNIV, DEPT METAB BIOCHEM, TOTTORI 680, JAPAN
[2] TANABE SEIYAKU CO LTD, SAFETY RES LAB, OSAKA 532, JAPAN
来源
JOURNAL OF VETERINARY MEDICAL SCIENCE | 1996年 / 58卷 / 10期
关键词
canine; immunohistochemistry; metallothionein; Northern blotting; olfactory pathway;
D O I
10.1292/jvms.58.10_983
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Dogs raised in the open air were used in this study. Metallothionein (MT) immunoreactivity was observed in the nucleus and/or cytoplasm of sustentacular cells of the olfactory epithelium in the nasal mucosa, whereas there was few MT-positive cells in the respiratory epithelium. MT immunoreactivity was also observed in astrocytes in all layers of the the olfactory bulb cortex; glial cells surrounding the glomeruli in the olfactory bulb showed prominent immunoreactivity for MT. Adult dogs exhibited stronger immunoreactivity for MT than young. Northern blot analysis demonstrated substantial levels of MT mRNA in the olfactory mucosa and olfactory bulb. Physiological roles of MT localized in the olfactory pathway of dogs were discussed.
引用
收藏
页码:983 / 988
页数:6
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